Management of Peyronie's disease: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)

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dc.authorid0000-0003-0125-673X
dc.contributor.authorChung, Eric
dc.contributor.authorZiegelmann, Matt
dc.contributor.authorLin, Hao Cheng
dc.contributor.authorJenkins, Lawrence
dc.contributor.authorBroderick, Gregory
dc.contributor.authorMoon, Du Geon
dc.contributor.authorSeyam, Raouf
dc.date.accessioned2026-01-31T15:08:37Z
dc.date.available2026-01-31T15:08:37Z
dc.date.issued2026
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractIntroduction There is no ideal treatment for Peyronie's Disease (PD) since every patient has different needs with varying perceived risks versus benefits of individual treatment options, coupled with the degree of impact relating to PD on sexual function and beyond.Objectives The 5th International Consultation on Sexual Medicine (ICSM) guideline on PD provides an update to the previous ICSM with an aim to provide a clinical framework and best-evidenced consensus recommendations to assist clinicians in managing PD.Methodology Available literature was reviewed, and a modified Delphi consensus was undertaken by leading sexual medicine experts to achieve a set of Quality of Evidence and strength of recommendations. This guideline was developed as an authoritative best-evidenced consensus incorporating state-of-the-art knowledge and contemporary literature.Results A total of thirty-one recommendations were made on PD guidelines. New updates to the 4th ICSM on PD have been made in definition, pathophysiology, and treatment strategies. The presence of penile pain with erection could occur in the chronic phase due to torque or stretch on the penile scar and surrounding tissue. Oral therapy works best during the acute phase and should be provided concurrently with other treatment modalities. Penile traction therapy can reduce penile deformity as monotherapy or may be offered as part of a multimodal therapy approach. There is no convincing evidence supporting cellular-based therapy. The type of plication procedure used depends on the surgeon and patient preference, although excision of the tunica followed by plication may have a higher complication rate. There is currently no ideal graft, and graft contracture can occur postoperatively. Adjunctive procedures such as penile modeling, tunical plication, plaque incision/excision and grafting can be performed when penile deformity and/or penile curvature persist following penile prosthesis implantation.Conclusions The management of PD should be individualized based on the patient's needs and preferences while balancing the benefits and risks of each treatment option.
dc.identifier.doi10.1093/sxmrev/qeaf068
dc.identifier.issn2050-0513
dc.identifier.issn2050-0521
dc.identifier.issue1
dc.identifier.pmid41359447
dc.identifier.scopus2-s2.0-105026704711
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org./10.1093/sxmrev/qeaf068
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10707
dc.identifier.volume14
dc.identifier.wosWOS:001632232700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofSexual Medicine Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectPeyronie's disease
dc.subjecterectile dysfunction
dc.subjectmedical therapy
dc.subjectsurgery
dc.subjectpenile reconstruction
dc.subjectclinical evidence
dc.subjectguideline
dc.titleManagement of Peyronie's disease: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024)
dc.typeReview Article

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