Synthesis and biological evaluation of novel nitrogen- and sulfur-containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agents

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dc.contributor.authorIbis, Cemil
dc.contributor.authorTuyun, Amac Fatih
dc.contributor.authorOzsoy-Gunes, Zeliha
dc.contributor.authorBahar, Hakan
dc.contributor.authorStasevych, Maryna V.
dc.contributor.authorMusyanovych, Rostyslav Ya.
dc.contributor.authorKomarovska-Porokhnyavets, Olena
dc.date.accessioned2024-03-13T10:34:55Z
dc.date.available2024-03-13T10:34:55Z
dc.date.issued2011
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstract1,4-Naphthoquinones are unique reagents in organic synthesis and have been employed in several well known and recently developed areas of application. Furthermore, these 1,4-naphthoquinones have demonstrated high reactivity in nucleophilic vinylic substitutions, in the preparation of sulfurated, (hetero)cyclic and several other transformations. This study describes the synthesis and biological evaluation of derivatives of monosulfurated naphthalene-1,4-dione (3), 3-chloro-2-ethoxy-naphthalene-1,4-dione (4), disulfurated naphthalene-1,4-dione (5), and symmetrical bis-1,4-naphthoquinones (7, 9) were obtained from the reaction of 2,3-dichloro-naphthaquinone (1) with S-, O-substituted mono-, di-, and tetrathiols, respectively. The structures of the novel products were characterized by spectroscopic methods. Crown Copyright (C) 2011 Published by Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipTUBITAK [109T617]; State Agency on Science, Innovations and Informatization of Ukraine [M/309-2011]en_US
dc.description.sponsorshipThe financial support from TUBITAK for Ukraine-Turkey agreement gratefully acknowledged (Project No. 109T617) and from State Agency on Science, Innovations and Informatization of Ukraine (Project No. M/309-2011).en_US
dc.identifier.doi10.1016/j.ejmech.2011.09.048
dc.identifier.endpage5867en_US
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue12en_US
dc.identifier.pmid22019185en_US
dc.identifier.scopus2-s2.0-80955137720en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5861en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2011.09.048
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4138
dc.identifier.volume46en_US
dc.identifier.wosWOS:000297874300015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal Of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activityen_US
dc.subjectAntifungal activityen_US
dc.subject2,3-Dichloro-1,4-naphthoquinoneen_US
dc.subjectAmino-sulfinylnaphthoquinoneen_US
dc.subjectQuinoneen_US
dc.titleSynthesis and biological evaluation of novel nitrogen- and sulfur-containing hetero-1,4-naphthoquinones as potent antifungal and antibacterial agentsen_US
dc.typeArticleen_US

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