Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study

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dc.contributor.authorKarakurt, Gokhan
dc.contributor.authorUcgun, Hikmet
dc.contributor.authorAynaci, Engin
dc.contributor.authorDuger, Mustafa
dc.contributor.authorDemir, Sukru E.
dc.date.accessioned2024-03-13T10:33:07Z
dc.date.available2024-03-13T10:33:07Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractINTRODUCTION The aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients. METHODS A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and were discharged from the hospital more than 3 months ago, were included in our study. The patients were divided into 3 groups according to the steroid doses they received. RESULTS The value of peak expiratory flow (PEF) was significantly lower in pulse-dose steroid group compared to high-dose steroid group (p=0.040). There was a significant difference in the values of carbon monoxide diffusion capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among all groups (p=0.027, p=0.048). The values of DLCO and DLCO/VA were significantly lower in the pulse-dose steroid group compared to the high-dose steroid group (p=0.022, p=0.049). The computed tomography (CT) score was significantly higher in the pulse-dose steroid group compared to both the nonsteroid group and high-dose steroid group (p=0.027, p=0.043). CONCLUSIONS Pulse-dose steroid therapy given in the acute period of COVID-19 pneumonia may negatively affect pulmonary function and recovery in the long-term. In addition, high-dose steroids were found to have a positive effect on pulmonary function compared to pulse-steroid therapy and nonsteroid therapy.en_US
dc.identifier.doi10.18332/pne/174604
dc.identifier.issn1105-848X
dc.identifier.issn1791-4914
dc.identifier.scopus2-s2.0-85179328818
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.18332/pne/174604
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3781
dc.identifier.wosWOS:001118606300001
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherEuropean Publishingen_US
dc.relation.ispartofPneumonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectDLCOen_US
dc.subjectpulmonary functionen_US
dc.subjectsteroiden_US
dc.titleLong-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort studyen_US
dc.typeArticleen_US

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