Oxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorder

Basit Öğe Kaydı
dc.contributor.authorTuran, Cetin
dc.contributor.authorSenormanci, Guliz
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorBudak, Yasemin
dc.contributor.authorErel, Ozcan
dc.contributor.authorSenormanci, Omer
dc.date.accessioned2024-03-13T10:33:29Z
dc.date.available2024-03-13T10:33:29Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) and the control group (CG). Serum thiol/disulfide balance and ischemia-modified albumin levels were studied to determine oxidative stress, and serum interleukin-6 (IL-6) levels and complete blood count (CBC) were to assess inflammation. Methods: Fifty patients with METH use disorder (MUD) and 36 CG participants were included in the study. Two tubes of venous blood samples were taken to measure oxidative stress, serum thiol/disulfide balance, ischemia-modified albumin, and IL-6 levels between groups. The correlation of parameters measuring oxidative stress and inflammation between groups with sociodemographic data was investigated. Results: In this study, serum total thiol, free thiol levels, disulfide/native thiol percentage ratios, and serum ischemia-modified albumin levels of the patients were statistically significantly higher than the healthy controls. No difference was observed between the groups in serum disulfide levels and serum IL-6 levels. Considering the regression analysis, only the duration of substance use was a statistically significant factor in explaining serum IL-6 levels. The parameters showing inflammation in the CBC were significantly higher in the patients than in the CG. Conclusion: CBC can be used to evaluate systemic inflammation in patients with MUD. Parameters measuring thiol/disulfide homeostasis and ischemia-modified albumin can be, also, used to assess oxidative stress.en_US
dc.identifier.doi10.9758/cpn.22.1047
dc.identifier.endpage582en_US
dc.identifier.issn1738-1088
dc.identifier.issn2093-4327
dc.identifier.issue3en_US
dc.identifier.pmid37424424en_US
dc.identifier.startpage572en_US
dc.identifier.urihttps://doi.org/10.9758/cpn.22.1047
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3978
dc.identifier.volume21en_US
dc.identifier.wosWOS:001030118500015en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Coll Neuropsychopharmacologyen_US
dc.relation.ispartofClinical Psychopharmacology And Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMethamphetamineen_US
dc.subjectAddictionen_US
dc.subjectInterleukin-6en_US
dc.subjectDisulfidesen_US
dc.subjectThiolsen_US
dc.subjectSerum albuminen_US
dc.titleOxidative Stress and Inflammatory Biomarkers in People with Methamphetamine Use Disorderen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu