Antidiabetic, Anticholinergic And Antioxidant Activities Of Aerial Parts Of Shaggy Bindweed (Convulvulus Betonicifolia Miller Subsp.) - Profiling Of Phenolic Compounds By LC-HRMS

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dc.authorid292052en_US
dc.authorid240179en_US
dc.authorid134001en_US
dc.authorid42091en_US
dc.authorid119165en_US
dc.contributor.authorKöse, Leyla Polat
dc.contributor.authorKızıltaş, Hatice
dc.contributor.authorGören, Ahmet C
dc.contributor.authorTopal, Meryem
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorAlwasel, Saleh H.
dc.contributor.authorGülçin, Ilhami
dc.date.accessioned2021-09-02T13:27:23Z
dc.date.available2021-09-02T13:27:23Z
dc.date.issued2021
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractIn order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract(WESB) of Shaggy bindweed (Convulvulus betonicifoliaMill. Subs), some putative antioxidant methods such asDPPH?scavenging activity, ABTS ?scavenging effect, ferric ions (Fe3?) reduction method, cupric ions (Cu2?)reducing capacity, and ferrous ions (Fe2?) binding activities were separately performed. Also, ascorbic acid,?-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds thatresponsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolutionmass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidantabilities when compared to standards. In addition, EESB demonstrated IC50values of 1.946?g/mL againstacetylcholinesterase (AChE), 0.815?g/mL against?-glycosidase and 0.675?g/mL against?-amylase enzymes.1. IntroductionShaggy bindweed (Convulvulus betonicifoliaMill. Subs) is endemicplant to Eastern Anatolia.Convolvulusspecies are used as a laxative inAnatolian folk medicine. Also, in some regions of Anatolia, convolvulusleaves are added to soup in kitchens [1]. This plant is a hairy herbaceousperennial that is drifting or climbing. Its leaves andflowers are solitary,axillary or in 2-5-flowered cymes. Its outer sepals hairy, oblong, sharp toacuminous. It usually grows in fallow or cultivatedfields, along road-sides, in dry ditches and at 30–1700 m altitude.The plants are known as productive and prolific haven of phyto-chemicals with unmatched therapeutic potentials. Moreover, worldwide28.000 plant taxa have been reported to have medicinal properties. It hasbeen recorded that more than 3000 species have ethnomedical applica-tions against many diseases including cancer [2]. According to recentstudies, the use of endemic and medicinal plants in the food,pharmaceutical and cosmetic industries is recently increasing. Mean-while, the majority of the world's population frequently uses herbalmedicine for basic health care [3]. Medicinal plants are an importantsource of nutrients and organic metabolites to protect human health.They are commonly used in developing countries and around the world,to treat some diseases especially in metabolic syndrome and diabetesmellitus [4]. It was reported that medicinal plants have many crucialpharmacological and biological effects such as antioxidant,anti-inflammatory, anticancer, and others. It is well known that theseplants have antioxidant effects and serve as sources of phenolic com-pounds [5,6].Antioxidant molecules are natural or synthetic substances, whichinhibit oxidation process and blocked the production of free radicals andreactive oxygen species (ROS) [7,8]. They can preserve the human bodyfrom undesired effects of ROS and oxidative stress [9,10]. Antioxidantshad beneficial effects in preventing of chronic diseases. They can easily* Corresponding author.E-mail addresses:igulcin@atauni.edu.tr,igulcin@yahoo.com(_I. Gulcin).Contents lists available atScienceDirectHeliyonjournal homepage:www.cell.com/heliyonhttps://doi.org/10.1016/j.heliyon.2021.e06986Received 28 February 2021; Received in revised form 21 March 2021; Accepted 29 April 20212405-8440/©2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Heliyon 7 (2021) e06986en_US
dc.identifier.citationHeliyon Volume 7, Issue 5, May 2021, e06986en_US
dc.identifier.doi10.1016/j.heliyon.2021.e06986
dc.identifier.issn1304-0057
dc.identifier.pmid34027185en_US
dc.identifier.scopus2-s2.0-85105537391en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2021.e06986
dc.identifier.wosWOS:000663597700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier SCI LTDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectShaggy bindweeden_US
dc.subjectConvulvulus betonicifoliaen_US
dc.subjectAntioxidant activityen_US
dc.subjectPolyphenol contenten_US
dc.subjectLC-HRMSen_US
dc.titleAntidiabetic, Anticholinergic And Antioxidant Activities Of Aerial Parts Of Shaggy Bindweed (Convulvulus Betonicifolia Miller Subsp.) - Profiling Of Phenolic Compounds By LC-HRMSen_US
dc.typeArticleen_US

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