Hyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress

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dc.authorid0000-0003-2290-7255
dc.authorid0000-0003-1358-9224
dc.authorid0000-0001-7616-3330
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorPolat, Fatin Rustu
dc.contributor.authorBicakci, Nurcan
dc.contributor.authorDuran, Yasin
dc.contributor.authorGunduz, Ihsan
dc.contributor.authorBeyaz, Yuksel
dc.date.accessioned2026-01-31T15:08:11Z
dc.date.available2026-01-31T15:08:11Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractAcute pancreatitis (AP) is a serious inflammatory condition of the pancreas often requiring hospitalisation and characterised by abdominal pain, nausea, and vomiting. Hyperin (HP), a natural flavonoid, possesses antioxidant and anti-inflammatory characteristics. However, the effect of HP on AP remains unclear. This study aimed to evaluate the protective effects of HP in a cerulein-induced AP model in rats, focusing on histopathological damage, inflammatory cytokines, and oxidative stress markers. All rats were randomly assigned into control (n = 8), AP (n = 8), and AP + HP (50 mg/kg) groups (n = 8). We created an AP rat model by intraperitoneal cerulein injections. We evaluated histopathologically pancreatic tissues using hematoxylin-eosin staining. NF-kappa B and TNF-alpha expressions were analysed using immunohistochemical method. Oxidative stress markers such as MDA, SOD, CAT, GPx as well as serum amylase and lipase levels were assessed using biochemical methods. IL-6 and IL-10 levels were measured using ELISA. HP treatment significantly reduced histological damage scores, including oedema, necrosis, and vacuolisation. Moreover, expression levels of NF-kappa B and TNF-alpha were markedly decreased in the AP + HP group. HP restored SOD activity and reduced MDA levels, indicating attenuated oxidative stress. HP decreased serum IL-6 and increased IL-10 levels, along with significant reductions in amylase and lipase. HP exerts both anti-inflammatory and antioxidant effects in cerulein-induced AP, primarily through NF-kappa B and TNF-alpha inhibition and SOD activation. These findings suggest that HP may be a promising natural compound for the adjunctive treatment of AP.
dc.description.sponsorshipScientific Research Project Fund of Tekirdag Namimath;k Kemal University [NKUBAP.02. GA.22.430]
dc.description.sponsorshipThis work is financially supported by the Scientific Research Project Fund of Tekirdag Nam & imath;k Kemal University (NKUBAP.02. GA.22.430).
dc.identifier.doi10.1007/s10735-025-10645-7
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue6
dc.identifier.pmid41128823
dc.identifier.scopus2-s2.0-105019536785
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org./10.1007/s10735-025-10645-7
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10617
dc.identifier.volume56
dc.identifier.wosWOS:001600493700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260128
dc.subjectHyperin
dc.subjectAcute pancreatitis
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectCerulein
dc.titleHyperin attenuates cerulein-induced acute pancreatitis by regulating inflammation and oxidative stress
dc.typeArticle

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