Changes in Serological Bone Turnover Markers in Bisphosphonate Induced Osteonecrosis of the Jaws: A Case Control Study

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dc.contributor.authorDemircan, Sabit
dc.contributor.authorIşler, SC
dc.date.accessioned2020-10-16T11:24:34Z
dc.date.available2020-10-16T11:24:34Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.descriptionPubmed'de indekslenmektediren_US
dc.description.abstractAbstract Background: There are a lot study confirmed the relationship of bone serum markers changes and skeletal irregularities. But there is no sufficient case control studies about the role of these markers on bisphosphonate induced osteonecrosis of jaws (BRONJ). Aims: The aim of this study is to find out if there is any derangement of bone markers in bisphosphonate-treated patients with ONJ. Methods: We obtained serum bone markers and other relevant endocrine assays on 20 patients with osteonecrosis of the jaw (ONJ) and 20 randomized healthy volunteers. All of the ONJ group treated with zoledronic acid and had been withdrawn from bisphosphonate for at least 6 months. Diagnostic criteria for ONJ were those formulated by the American Association of Oral and Maxillofacial Surgeons. Serum levels of several indices of bone remodeling were evaluated using commercial enzyme-linked immunosorbent assays. The biochemical assays were performed on N-Telopeptides of type I collagen (NTX), bone-specific alkaline phosphatase (ALP), calcitonin, osteocalcin, intact parathyroid hormone (PTH), T3, T4, TSH, and Vitamin D 25 hydroxy (Vit-D). Results: In ONJ group, PTH level is statistically higher and TSH, Vit-D, osteocalcin and NTX levels statistically lower compared to control group. Conclusion: We conclude that these changes in PTH, Vit-D, TSH, osteocalcin and NTX levels maybe have a role in the pathophysiology of BRONJ. But the data need to be confirmed by future studies. Keywords: Bisphosphonate; bone markers; bone metabolism; oral pathology; osteonecrosis.en_US
dc.identifier.citationNıgerıan Journal Of Clınıcal Practıce 23,(2) 154-158 2020en_US
dc.identifier.doi10.4103/njcp.njcp_374_19
dc.identifier.issn1333-1486
dc.identifier.pmid32031088en_US
dc.identifier.scopus2-s2.0-85079081665en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_374_19
dc.identifier.wosWOS:000514446300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedical and Dental Consultants’ Association of Nigeriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectBisphosphonateen_US
dc.subjectBone Markersen_US
dc.subjectOsteonecrosisen_US
dc.subjectBone Metabolismen_US
dc.subjectOral Pathologyen_US
dc.titleChanges in Serological Bone Turnover Markers in Bisphosphonate Induced Osteonecrosis of the Jaws: A Case Control Studyen_US
dc.typeArticleen_US

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