Exploring the Modulatory Effects of Vitamin B12 on Morphine-Induced Conditioned Place Preference in Rats

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dc.authorid0000-0002-6144-5148
dc.authorid0000-0001-7566-2170
dc.contributor.authorUskur, Tugce
dc.contributor.authorTasdemir, Fatma Unlu
dc.contributor.authorOzturk, Mehmetaykut
dc.contributor.authorSonmez, Haktan
dc.contributor.authorSeven, Zeynep Gizem Todurga
dc.contributor.authorGokdemir, Selim
dc.contributor.authorBastan, Burak
dc.date.accessioned2026-01-31T15:09:09Z
dc.date.available2026-01-31T15:09:09Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBackground: This study aims to investigate the effects of vitamin B12 on morphine-induced conditioned place preference (CPP), a model commonly used to assess the rewarding effects of drugs. Morphine is a potent analgesic widely used for moderate to severe pain, but it also poses a significant risk of addiction. Previous studies suggest that cyanocobalamin (vitamin B12) may enhance the analgesic effects of morphine and reduce tolerance, but its impact on morphine addiction remains unclear. Methods: The experiment followed phases of habituation, pre-conditioning, conditioning, and post-conditioning. Adult male Wistar albino rats (250-300 g) were randomly divided into 3 groups (n = 8 per group): control (saline), morphine (10 mg/kg), and a combination group of vitamin B12 (2 mg/kg) with morphine. The effects of saline, morphine, and the morphine-vitamin B12 combination on CPP were assessed. All drugs and saline were administered intraperitoneally (ip). Results: Morphine (10 mg/kg) significantly induced CPP compared to the saline group (P < .0001). Vitamin B12 (2 mg/kg) did not produce a statistically significant difference in morphine-induced CPP compared to the control group. Conclusion: Morphine induces a significant place preference, and vitamin B12 did not produce a statistically significant difference in reducing this effect. Further research with different doses of vitamin B12 is necessary to fully investigate these effects.
dc.identifier.doi10.5152/pcp.2025.241005
dc.identifier.endpage274
dc.identifier.issn2475-0573
dc.identifier.issn2475-0581
dc.identifier.issue3
dc.identifier.pmid40824234
dc.identifier.scopus2-s2.0-105012591121
dc.identifier.scopusqualityQ4
dc.identifier.startpage269
dc.identifier.trdizinid1361095
dc.identifier.urihttps://doi.org./10.5152/pcp.2025.241005
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1361095
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10841
dc.identifier.volume35
dc.identifier.wosWOS:001548315400009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAves
dc.relation.ispartofPsychiatry And Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260128
dc.titleExploring the Modulatory Effects of Vitamin B12 on Morphine-Induced Conditioned Place Preference in Rats
dc.typeArticle

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