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Öğe Biological Variation Of Glycated Albumin, Glucose And Albumin İn Healthy Turkish Subjects(De Gruyter [Commercial Publisher], 2021) Hocaoğlu Emre, Fatma Sinem; Mercan, Hilal; Oğuz, OsmanObjectives: Biological variation (BV) in laboratory tests can be defined as the variation in analyte concentration over time within and between individuals. Glycated albumin (GA) is a ketoamine which is used in the short-term monitoring of diabetes. The aim of this research was to determine BV of GA, glucose, and albumin under a well-designed and standardized protocol. Methods: Blood samples were collected weekly from 21 healthy subjects (10 males, 11 females) for four consecutive weeks. Samples were analyzed using enzymatic methods in duplicate. After subjected to outlier and normality tests, variables as the within-subject biologic coefficient of variation (CVI) and between-subject biologic coefficient of variation (CVG), the index of individuality (II), and reference change value (RCV) were calculated. Results: Analytical coefficient of variation (CVA) was 3.5, 1.78, and 2.9%, for GA, glucose and albumin, respectively. The estimates for CVI and CVG: GA: 4.1%, 6.3%; glucose: 3.8%, 4.8%; albumin: 3.5%, 4%. RCVs and IIs were: 15%, 0.60; 12%, 0.79; 13%, 0.9 for GA, glucose and albumin, respectively. Conclusions: The BV data of GA derived from this study might be applied to understand routine test results better and establish the quality standards for the analyte. KeywordsÖğe Evaluation of Hemoglobin and Hematocrit Values by the CO-Oximetry and Cyanide-Free Sodium Lauryl Sulphate Methods: A Retrospective Study(GALENOS PUBL HOUSE, 2022) Hocaoğlu, Fatma Sinem; Serin, Huriye; Oğuz, OsmanIntroduction: Blood gas analyzers (BGA) have recently been widely used as a rapid testing devices for the determination of hemoglobin (Hb) in the intensive care units and emergency services of hospitals. We compared the Hb and calculated hematocrit (Hct) values by the CO-oximetry and cyanide-free sodium lauryl sulphate (SLS) methods. Methods: Between January and June 2019, 12,049 patients who applied to the emergency department of İstanbul Training and research Hospital, for whole blood count and venous blood gas analysis were included. Samples were analyzed using SLS- Hb and CO-oximetry methods. Bland-Altman plot and Passing-Bablok regression analysis were performed to evaluate the accordance of the methods. Results: The correlation coefficients of the methods for Hb and Hct were 0.89 and 0.87, respectively (p<0.0001). Passing Bablok regression analysis showed a significant deviation from linearity (p<0.01). Bland-Altman plot showed insufficient agreement between of the two methods for each variable. Bias % calculated as 2.5% for Hb, and 1.1% for Hct. Total error calculated as 4.08% for Hb. Total error of CO-oximetric Hb value was within the limits of allowable total error. Conclusion: Although each test shows a significant deviation from linearity, BGA’s could be used for Hb measurements since the bias and total error were still acceptable.Öğe Prevalence of Anemia and Iron Deficiency Anemia Among Elementary School Children in Turkey(Annals of Medical Research, 2021) Hocaoğlu Emre, Fatma Sinem; Oğuz, OsmanAim: The purpose of our study was to determine the rate of anemia and iron store status in Turkish elementary school children. Materials and Methods: We included 1296 children applied to pediatrics department of a large teaching hospital and evaluated the hemoglobin, iron, unsaturated iron binding capacity and ferritin levels. Results: The results showed that 9.88% of the children had anemia and 1.62% had iron-deficiency anemia. Despite the normal Hemoglobin (Hb) levels, the ratio of children with low ferritin levels was found to be 36.49%, suggesting that children with normal Hb levels might not be having adequate level of iron stored. The Hb levels were found to be significantly lower in the group of 6- and 7-year old children when compared to other ages. Conclusion: Being an elementary issue for normal growth and academic success in school, iron status should be closely monitored in school children. Additionally, different age groups have different needs for iron supplementation; therefore contemporary guidelines for the management of anemia in children should be established by authorities.Öğe Vitamin D Deficiency and Insufficiency According to the Current Criteria for Children: Vitamin D Status of Elementary School Children in Turkey(Galenos Publishing House, 2019) Hocaoğlu Emre, Fatma Sinem; Sarıbal, Devrim; Oğuz, OsmanObjective: This study aimed to determine the ratio of seasonal vitamin D deficiency and insufficiency in elementary school children aged between 6-9 years old, living in one of the largest metropols of Europe, İstanbul. Methods: Serum 25(OH)D levels of 640 children aged 6-9 years old were scanned retrospectively from the hospital information system records between September 2017-August 2018 period. Vitamin D deficiency was defined as a serum 25(OH)D level less than 12 ng/mL (30 nmol/L) and insufficiency as levels between 12 and 20 ng/mL (30-50 nmol/L). Results: Serum 25(OH)D levels ranged from 3.90 to 64.60 ng/mL, the median value was 25.95 ng/mL for all subjects. Of all the primary school children, 485 (75.78%) had adequate levels of 25(OH)D. Vitamin D deficiency was observed in 36 of children (5.62%), whereas insufficient levels of 25(OH)D were found in 119 children (18.60%). The ratio of vitamin D insufficiency and deficiency together was highest in spring (31.87%) and lowest in summer (13.12%). Conclusion: Vitamin D deficiency is a widely observed and preventable public health problem among children of different ages. It is necessary to increase the awareness among health professionals, and providing 25(OH)D supplements will yield generations with healthy bone structure and well growth.
