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Öğe Evaluation of the Golden Ratio in Nasal Conchae for Surgical Anatomy(SAGE, 2021) Petekkaya, Emine; Ulusoy, Mahinur; Bagheri, Hassan; Şanlı, Şükrü; Ceylan, Mehmet Seyit; Dokur, Mehmet; Karadağ, MehmetPurpose: The golden ratio is reached by the fractal model of the number sequence which is known as the ‘‘Fibonacci series’’ and has a convergent ratio of approximately 1.618 between 2 consecutive Fibonacci numbers. Golden ratio relationships have been shown in several plants in the nature and several organs and structures in the human body. The conchae, which form an important part of the nasal valve, have a special geometric significant in terms of providing turbulence to the laminar airflow that passes to the nasal cavity. Methods: This study made golden ratio calculations on 34 adults aged 20 to 45 years over computed tomography (CT) images. Totally, 34 volunteers (male, n ¼ 18 and female, n ¼ 16) with no nasal pathologies participated in the study. Using Adobe Photoshop, golden ratio calculations were made by applying the Fibonacci spiral on the images that best showed the conchae and meatuses on the CT images. Results: The intersection points of the spiral that was projected on the inferior and middle nasal concha were determined as S0, S1, S2, S3, and S4. The distances of S0-S1, S1-S2, S2-S3, and S3-S4 were measured. The concha measurements of the women showed significantly similar values to the golden ratio constant of *1.618 in the RS3/S4 and LS3/S4 measurements. Conclusion: We found that the S3/S4 region that captured the golden ratio in our study corresponds to the base part of the inferior nasal concha, and its place of spiraling in the nasal cavity is observed to have an important role in creating vorticesÖğe Evaluation of the Relationship between Cancer and Antioxidants from an Altmetric Perspective(2022) Guney, Turkan; Dokur, Mehmet; Vardar, Gökay; Hanikoğlu, Ferhat; Karadağ, MehmetObjectives: Antioxidants have been shown in research to have significant effects on serious diseases, particularly cancer. The goal of our experiment was to determine and analyzed 100 articles with the highest Altmetric attention scores (AAS) concerning antioxidants and cancer. Methods: Altmetric score analyzes were obtained downloading the from the Altmetric.com website. A research output's altmetric score was calculated using an algorithm based on the weighted number of all attention it receives. Results: The Altmetric scores of the 100 articles analyzed varied from 12 to 846. Twitter (n=86) was the most mentioned social media network in the articles. According to the research categories of the T100 articles in our analysis, the majority were published in "Medical and Health Science''. In terms of Twitter geographical breakdown, the United States leads among other nations, followed by the United Kingdom. According to Twitter demographics, the most of tweets on antioxidants and cancer were shared by members of the public. Conclusion: In science and research, social media is advocated as an alternative to traditional power structures and our findings could provide a preliminary look at the social, clinical, and academic impact of antioxidant and cancer research.Öğe Media-Based Clinical Research On Selfie-Related İnjuries And Deaths(Ulusal Travma ve Acil Cerrahi Derneği, 2018) Petekkaya, Emine; Dokur, Mehmet; Karadağ, MehmetAMAÇ: Yoğun olarak özçekim ve bunları sosyal medyada paylaşmak ya da bununla ilişkili davranışlar, özellikle gençler arasında giderek artmaktadır. Bu durum özçekim nedenli travmalara yol açabilir. Bu klinik çalışmayı, özçekim ilişkili yaralanma ve ölümlere dikkat çekmek için gerçekleştirdik. GEREÇ VE YÖNTEM: Çalışmamızda medya kaynaklarında rapor edilen 111 özçekim olayı veya kazası ile ilişkili 159 olgu değerlendirildi. Özçekimle ilişkili yaralanma ve ölümlerin nedenleri ile birlikte kurbanların vital bulguları, demografileri, ritmisiteleri, tercihler, olay veya kaza tipleri, risk faktörleri ve etkilenen vücut bölgeleri değerlendirildi. BULGULAR: Özçekim kurbanlarının birçoğunun öğrenci olduğu belirlendi. Özçekim ilişkili yaralanma ve ölümler en sık Hindistan, ABD ve Rusya'dan bildirilmişti. Kurbanların en sık poz tercihi uçurum kenarı idi. En sık rapor edilen kaza tipi yüksekten zemine düşme idi. Özçekim ilişkili yaralanma ve ölümlerde en sık etkilenen çoklu vücut bölgesi idi. En sık saptanan ölüm nedeni multitravma ve suda boğulma idi. TARTIŞMA: Özçekim ilişkili yaralanma ve ölümler son yıllarda giderek artmaktadır. Özellikle ergenler ve genç yetişkinler tehlikeli özçekim açısından yüksek risk taşırlar. Bu nedenle özçekim ilişkili yaralanma ve ölümleri azaltmak için bilinçlendirme yapılmalıdır.Öğe Protective and therapeutic effects of milrinone on acoustic trauma in rat cochlea(Springer, 2019) Ceylan, Seyit Mehmet; Uysal, Erdal; Altinay, Serdar; Sezgin, Efe; Bilal, Nagihan; Petekkaya, Emine; Dokur, MehmetObjectiveThe aim of this study was to investigate the potential protective and therapeutic effects of milrinone, a specific phosphodiesterase (PDE) III inhibitor, on acoustic trauma-induced cochlear injury and apoptosis.MethodsA total number of 30 healthy Wistar albino rats were evenly divided into five groups as follows: group 1 was assigned as control group; group 2 and 3 were assigned as low-dosage groups (0.25mg/kg) in which milrinone was administered 1h before acoustic trauma (AT) and 2h after AT, respectively; group 4 and 5 were assigned as high-dosage groups (0.50mg/kg) in which the drug was administered 1h before AT and 2h after AT, respectively. Except control group, all treatment groups received a single dosage of milrinone for 5days. Distortion product otoacoustic emissions (DPOAE) measurements were recorded before AT as well as at second and fifth post-traumatic days. At the end of fifth day, all rats were sacrificed and the cochlea of the rats was removed for histopathological evaluation. In addition, the groups were compared in terms of apoptotic index via caspase-3 staining.ResultsIn terms of signal-to-noise ratio (SNR), there was no statistically significant difference among the groups following AT (p>0.05). After 5days of milrinone treatment, the best SNR values were found in group 5, though all groups did not statistically differ (p>0.05). In histopathological evaluation, vacuolization, inflammation, and edema scores in all treatment groups were statistically lower than those of the control group (p<0.05). In group 2 and 4 where the drug was administered before AT, the inflammation and apoptosis index was lower than those of group 3 and 5 where the drug was administered after AT (p<0.0001).ConclusionWe reveal that milrinone has a protective effect on cochlear damage in the experimental acoustic model of rats. This protective effect was more apparent following the pre-traumatic milrinone administration, and is associated with its effect on decreasing inflammation and apoptosis. Based on DPOAE measurements following AT, especially in the group 5 (high-dosage group), milrinone may also have a therapeutic effect.Öğe Targeting the PANoptosome with 3,4-Methylenedioxy-?-Nitrostyrene, Reduces PANoptosis and Protects the Kidney against Renal Ischemia-Reperfusion Injury(Taylor & Francis Inc, 2022) Uysal, Erdal; Dokur, Mehmet; Kucukdurmaz, Faruk; Altinay, Serdar; Polat, Sait; Batcioglu, Kadir; Sezgin, EfeObjectives: The objectives of this study were a) to investigate the effect of targeting the PANoptosome with 3,4-methylenedioxy-beta-nitrostyrene (MNS) on PANoptosis in the Renal ischemia-reperfussion (RIR) model b) to investigate the kidney protective effect of MNS toward RIR injury. Methods: Thirty-two rats were divided into four groups randomly. The groups were assigned as Control, Sham, DMSO (dimethyl sulfoxide) and MNS groups. The rats in the MNS group were intraperitoneally given 20 mg/kg of MNS 30 minutes before reperfusion. 2% DMSO solvent that dissolves MNS were given to the rats in DMSO group. Left nephrectomy was performed on the rats under anesthesia at the 6th hour after reperfusion. Glutathione peroxidase (GPx), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and 8-Okso-2'-deoksiguanozin (8-OHdG) levels were measured. Immunohistochemical analysis, electron microscopic and histological examinations were carried out in the tissues. Results: Total tubular injury score was lower in the MNS group (p < 0.001). Caspase-3, Gasdermin D and MLK (Mixed Lineage Kinase Domain Like Pseudokinase) expressions were considerably decreased in the MNS group (p < 0.001). Apoptotic index (AI) was found to be low in the MNS group (p < 0.001). CAT and SOD levels were higher in the MNS Group (p = 0.006, p = 0.0004, respectively). GPx, MDA, and 8-OH-dG levels were similar (p > 0.05) in all groups. MNS considerably improved the tissue structure, based on the electron microscopic analysis. Conclusions: Our results suggested that MNS administrated before the reperfusion reduces pyroptosis, apoptosis and necroptosis. These findings suggest that MNS significantly protects the kidney against RIR injury by reducing PANoptosis as a result of specific inhibition of Nod-like receptor pyrin domain-containing 3 (NLRP 3), one of the PANoptosome proteins.
