Incidence and clinical management of vertebral anomalies in myelomeningocele: a retrospective analysis of 422 cases

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dc.contributor.authorSever, Cem
dc.contributor.authorAlataş, Ibrahim
dc.contributor.authorAy, Larisa Andrada
dc.contributor.authorSezen, Gulseli Berivan
dc.contributor.authorUgurlar, Doğa
dc.contributor.authorSanlier, Nafiye
dc.contributor.authorÖzel, Şeyhmus Kerem
dc.date.accessioned2026-01-31T15:04:23Z
dc.date.available2026-01-31T15:04:23Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractOBJECTIVE Myelomeningocele (MMC) is a severe neural tube defect frequently associated with vertebral anomalies, including scoliosis and kyphosis, which can significantly impact mobility and quality of life. This study aimed to evaluate the incidence and clinical correlations of scoliosis and other vertebral anomalies in children with MMC. METHODS A retrospective analysis of the hospital records of 422 pediatric MMC patients diagnosed between 2013 and 2020 at two tertiary care centers was conducted. Patients were evaluated for scoliosis, kyphosis, hemivertebra, butterfly vertebra, block vertebra, and diastematomyelia using radiographic and MRI findings. The severity of scoliosis was assessed using Cobb angles, and statistical analyses were performed to determine associations between vertebral anomalies. RESULTS Scoliosis was identified in 55.9% of patients (mean Cobb angle 35.65°), while kyphosis was present in 41.2%. The presence of hemivertebra and butterfly vertebra was strongly associated with scoliosis progression. Additionally, patients with split cord malformations exhibited a higher incidence of scoliosis and kyphosis. Age was found to be a key factor in scoliosis severity, with curve progression observed over time. CONCLUSIONS Scoliosis and other vertebral anomalies are highly prevalent in MMC patients, necessitating early diagnosis and multidisciplinary management. These findings underscore the importance of long-term monitoring and individualized treatment approaches to optimize spinal health and functional outcomes. ©AANS 2025, except where prohibited by US copyright law.
dc.identifier.doi10.3171/2025.5.PEDS24548
dc.identifier.endpage629
dc.identifier.issn1933-0707
dc.identifier.issue5
dc.identifier.pmid40779802
dc.identifier.scopus2-s2.0-105020687009
dc.identifier.scopusqualityQ1
dc.identifier.startpage621
dc.identifier.urihttps://doi.org/10.3171/2025.5.PEDS24548
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10529
dc.identifier.volume36
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmerican Association of Neurological Surgeons
dc.relation.ispartofJournal of Neurosurgery: Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260128
dc.subjectcongenital
dc.subjectkyphosis
dc.subjectmyelomeningocele
dc.subjectscoliosis
dc.subjectspinal deformities
dc.subjectspine
dc.subjectsurgical technique
dc.subjectsyringomelia
dc.subjectvertebral anomalies
dc.titleIncidence and clinical management of vertebral anomalies in myelomeningocele: a retrospective analysis of 422 cases
dc.typeArticle

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