Composing an Adhesion Barrier Using Hyaluronic Acid and Carboxymethylcellulose to Prevent Mediastinal Adhesion

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dc.contributor.authorAkçıl, Ali Murat
dc.contributor.authorDemirkaya, Ahmet
dc.contributor.authorErşen, Ezel
dc.contributor.authorCeviz, Fatma Şimşek
dc.contributor.authorRamazanoglu, Sultan Rana
dc.contributor.authorÖz, Buge
dc.contributor.authorKaynak, Mehmet Kamil
dc.date.accessioned2025-03-09T10:53:17Z
dc.date.available2025-03-09T10:53:17Z
dc.date.issued2023
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractObjective: Remediastinal intervention is an indispensable procedure to assess mediastinal lymph node metastasis after induction chemotherapy in patients with non-small cell lung cancer. Remediastinal interventions can be a difficult procedure because adhesions from a prior mediastinoscopy may reduce the surgeon’s field of view and may cause difficulty in diagnosing a lymph node, which causes suspicion about invasion. There are several adhesion barrier procedures, which were used to prevent postoperative adhesions, but none of them provided remarkable results. There are studies including abdominal, gynecologic, and neurochirurgic surgery; however, there is no sufficient study regarding mediastinum. In this study, we have explored the role of hyaluronic acid and carboxymethylcellulose in preventing mediastinal adhesion. Methods: In our study, 21 New Zealand-type male and female rabbits—each with a weight of 2500-3500 g—were used. Three groups, each including 7 rabbits, were set up using randomized sampling method. Mediastinal dissection was performed in the first group and Seprafilm® was used to build adhesion inhibition. Mediastinal dissection was performed in the second group, and 0.9% NaCl was used to build adhesion inhibition. In the control group, all layers were sutured primarily after mediastinal dissection. The rabbits were sacrificed after 30 days and each group was compared with the control group, using macroscopic and microscopic adhesion criteria. Results: According to the results of our study, Seprafilm® was found to be statistically efficient in preventing and decreasing adhesion in mediastinum (P < .01 in macroscopic criteria, P < .05 in inflammation, and vascular proliferation criteria). Conclusion: Seprafilm® can be used as an adhesion barrier in prevention of adhesions that develop as a result of surgery.
dc.identifier.doi10.5152/cjm.2023.23049
dc.identifier.endpage284
dc.identifier.issn2687-1904
dc.identifier.issue3
dc.identifier.startpage279
dc.identifier.trdizinid1258411
dc.identifier.urihttps://doi.org/10.5152/cjm.2023.23049
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1258411
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4779
dc.identifier.volume47
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCerrahpaşa Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250310
dc.subjectMediastinoscopy
dc.subjectmediastinal adhesion
dc.subjectremediastinoscopy
dc.subjectsodium hyaluronate–carboxymethylcellulose
dc.titleComposing an Adhesion Barrier Using Hyaluronic Acid and Carboxymethylcellulose to Prevent Mediastinal Adhesion
dc.typeArticle

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