Histopathological Changes in The Spinal Cord Tissue of Rats Administered an Experimental Mussel Diet

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dc.contributor.authorÜnlü, İlker
dc.contributor.authorÖzdemir, Ilhan
dc.contributor.authorTuncer, Mehmet Cudi
dc.contributor.authorÖztürk, Şamil
dc.date.accessioned2025-03-09T10:53:14Z
dc.date.available2025-03-09T10:53:14Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractAim: Regional eating habits show that it causes neurodegenerative problems due to heavy metals that can accumulate in consumed foods and affect tissues such as the nervous system. Since crustaceans such as mussels feed by filtering the water, they are exposed to toxic plankton and various chemicals, especially heavy metals. Due to the limitations of experimental studies on this subject, the effects of mussel consumption on the spinal cord were investigated. Methods: In this study, histopathological changes in the spinal cord tissue of rats fed with shellfish collected from the Dardanelles were determined. The subjects were divided into two groups, and the first group was fed standard rat food for 4 weeks, and the second group was fed a mussel diet. At the end of the study, spinal cord tissue samples taken from rats were subjected to routine histopathological procedures and evaluated under a light microscope. Results: In the experimental group, a decrease in the number of neurons in the medulla spinalis and an increase in the number of astrocytes were noted. TUNEL staining showed that apoptosis occurred intensively in glial cells, but did not occur in anterior and posterior horn motor neurons. Conclusion: The findings showed that long-term mussel consumption can cause axonal damage in motor and sensory neurons and degeneration in glial cells. For this reason, it is important for health that marine diets in coastal areas are made with healthy and hygienic products.
dc.identifier.doi10.5798/dicletip.1552285
dc.identifier.endpage296
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue3
dc.identifier.startpage289
dc.identifier.trdizinid1263764
dc.identifier.urihttps://doi.org/10.5798/dicletip.1552285
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263764
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4753
dc.identifier.volume51
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofDicle Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250310
dc.subjectApoptosis
dc.subjectMedulla spinalis
dc.subjectmussel
dc.subjectneuronal degeneration
dc.titleHistopathological Changes in The Spinal Cord Tissue of Rats Administered an Experimental Mussel Diet
dc.typeArticle

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