In silico Analysis of Virulence, Resistance Genes and Phylogeny of Helicobacter pylori Strains from Different Continents
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Tarih
2021
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Helicobacter pylori (H. pylori) is a bacterium that infectsthe gastric mucosa of 50% of the world population. It is known thatdifferent regional treatment practices used against the infectionsof H. pylori affect both the expression of virulence and antimicrobi- al resistance genes, giving the bacteria geographic differentiation.The aim of this study was to perform in silico analysis of virulence,resistance genes and phylogeny of H. pylori strains obtained frompeople living in different continents.Material and Method: Complete gene sequences of 18 H. pyloristrains from six continents were downloaded from the NationalCenter for Biotechnology Information (NCBI) database. The phy- logeny of the strains, resistance and virulence genes were analyzedby CSI phylogeny, CARD and VFanalyzer, respectively.Results: African strains were the most distant identity to Europe- an strains.A2147G single nucleotide polymorphismassociatedwith clarithromycin resistance was detected in South Americanand Asian origin. It was determined that strains were differentiatedby a total of 95 related virulence genes under eight headings. ThecagA, cagE, cagL and vacA genes were found in all strains in Asia.Conclusion: In conclusion, our study demonstrated that H. pyloristrains, whose data were collected in different continents, differfrom each other in terms of similarities and there is a serious differ- ence especially in terms of virulence genes.
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EXPERIMED
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Cilt
11
Sayı
3
