Antimicrobial effect of local anesthetics on Helicobacter pylori

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dc.contributor.authorKesıcı, Ugur
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorAtilla Yılmaz
dc.date.accessioned2025-03-09T18:06:51Z
dc.date.available2025-03-09T18:06:51Z
dc.date.issued2021
dc.departmentBeykent Üniversitesi
dc.description.abstractBackground/Aim: Helicobacter pylori (HP) is a gram-negative bacillus, with a prevalence of 50% throughout the world. HP infection is considered the strongest etiological factor for gastric cancer (GC). Therefore, early diagnosis and treatment of HP can be considered as the primary prevention strategy for the development of GC. This study aimed to reveal the antimicrobial effect of commonly used local anesthetics (LAs) on HP. The literature review in English has revealed no study on this subject. Methods: This in vitro laboratory study was conducted in a University laboratory between 25 October 2019 and 1 November 2019. In the study, antimicrobial effect of 1 mL sterile saline, 20 mg/mL lidocaine, 1 mg/mL adrenaline, 10 mg/mL prilocaine, 50 mg/mL bupivacaine, and 20 mg+0.0125 mg/mL lidocaine plus adrenaline against H. pylori strain NCTC 11637 obtained from National Collection of Type Cultures (NCTC) were tested in vitro. The groups were designated as follows: Group C (Control), Group B (Bupivacaine), Group L (Lidocaine), Group A (Adrenaline), Group P (Prilocaine), and Group LA (Lidocaine plus adrenaline). HP strain NCTC 11637 was cultured in Mueller Hinton agar (Oxoid, UK) supplemented with 5% sheep blood plates at 37°C under microaerophilic conditions (5% oxygen, 10% carbon dioxide, and 85% nitrogen gas combination) for 72 hours. Results: Antimicrobial activity was observed in Group L and Group LA. No antimicrobial action against HP was observed in other groups. The comparison of groups in terms of inhibition zone diameters showed that there was a statistically significant inhibiting effect in Group L and Group LA compared to Group C (P=0.002 and P
dc.identifier.doi10.28982/josam.741301
dc.identifier.endpage233
dc.identifier.issn2602-2079
dc.identifier.issue3
dc.identifier.startpage230
dc.identifier.urihttps://doi.org/10.28982/josam.741301
dc.identifier.urihttps://hdl.handle.net/20.500.12662/5086
dc.identifier.volume5
dc.language.isoen
dc.publisherFatih BAŞAK
dc.relation.ispartofJournal of Surgery and Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250309
dc.subjectHelicobacter pylori
dc.subjectantimicrobial
dc.subjectlidocaine
dc.subjectadrenaline
dc.subjectbupivacaine
dc.subjectprilocaine
dc.titleAntimicrobial effect of local anesthetics on Helicobacter pylori
dc.typeArticle

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