Prognostic Significance of Glutathione Peroxidase (GSH-Px) Levels in Lumbar Degenerative Disc Disease [Lomber Dejeneratif Disk Hastalığında Glutatyon Peroksidaz (GSH-Px) Düzeylerinin Prognostik Önemi]

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dc.contributor.authorYaltırık C.K.
dc.contributor.authorYılmaz S.G.
dc.contributor.authorAkdeniz F.T.
dc.contributor.authorSümerkent K.
dc.contributor.authorÖzdoğan S.
dc.contributor.authorİsbir T.
dc.date.accessioned2024-03-13T10:01:13Z
dc.date.available2024-03-13T10:01:13Z
dc.date.issued2020
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractObjective: In this study, the main aim was to research whether decreased antioxidant activity was manifesting the intervertebral disc degeneration in a population in which the degeneration could be compatible with their ages. Material and Method: The study group consisted of 39 patients with lumbar disc degeneration (LDD) and 37 healthy controls. Patient data including age, symptoms, neurological examination findings, lumbar MRI findings, Oswestry Disability Index (ODI) scores, and Visual Analogue Scale of pain (VAS) were used. Human Glutathione peroxidase (GSH-Px) level was determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: Serum GSH-Px levels were significantly lower in the patients with LDD when compared to the healthy controls (p=0.011). Conclusions: In the present study, we demonstrated that, in addition to environmental factors, there is a correlation between GSH-Px enzyme deficiency and lumbar disc degeneration. © 2020, Istanbul University Press. All rights reserved.en_US
dc.description.sponsorshipYeditepe Üniversitesien_US
dc.description.sponsorshipFinancial Disclosure: The present study was supported by Yeditepe University Project Management Office.en_US
dc.identifier.doi10.26650/experimed.2020.0011
dc.identifier.endpage71en_US
dc.identifier.issn2667-5846
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85173984183en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.26650/experimed.2020.0011
dc.identifier.urihttps://hdl.handle.net/20.500.12662/3060
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIstanbul University Pressen_US
dc.relation.ispartofExperimeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectELISAen_US
dc.subjectGlutathione peroxidaseen_US
dc.subjectlumbar degenerative disc dis-easeen_US
dc.titlePrognostic Significance of Glutathione Peroxidase (GSH-Px) Levels in Lumbar Degenerative Disc Disease [Lomber Dejeneratif Disk Hastalığında Glutatyon Peroksidaz (GSH-Px) Düzeylerinin Prognostik Önemi]en_US
dc.typeArticleen_US

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