Infectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia

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dc.contributor.authorYetkin, Gülay İmadoğlu
dc.contributor.authorTaşçioglu, Didem Akal
dc.contributor.authorÖztürk, Selçuk
dc.contributor.authorCuglan, Bilal
dc.contributor.authorYalta, Kenan
dc.contributor.authorYetkin, Ertan I.
dc.date.accessioned2026-01-31T15:04:20Z
dc.date.available2026-01-31T15:04:20Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractBackground: Although the mechanism of coronary artery ectasia (CAE) shares the common pathophysiologic steps resembling those of atherosclerosis, there are certain discrepancies or aspects incompatible with atherosclerosis. Therefore, we hypothesize that the pathophysiology of CAE might differ from that of atherosclerosis in terms of inflammatory parameters, infectious agents and the read out of protein electrophoresis. Materials and methods: Seventy patients with coronary artery disease (CAD) and 30 patients with both CAD and CAE comprised the study populations. Blood samples were centrifuged for the measurement of IgG antibodies against C.pneumoniae and H.Pylori, alongside with total IgE, IgG levels and protein electrophoresis. Results: There were not statistically significant differences between patients with and without CAE regarding the complete blood counting and routine biochemical laboratory parameters except hemoglobin levels. Among other studied laboratory parameters, IgE, Alpha 2 macroglobulin, Beta-1 globulin levels were found to be higher in patients with CAE + CAD than those of CAD alone. Logistic regression analysis by including the variables IgE, Hb, Alpha 2 macroglobulin, beta-1 globulin, and gender, revealed that Ig E (Odd ratio:1.004 85 % CI: 1.000–1.008, p = 0.01) and alpha 2 macroglobulin (Odds ratio: 9.41, 95 %CI: 1.69–52.28, p = 0.028) were independently and positively associated with the presence of CAE. Conclusion: Independent association of serum IgE levels and alpha2 globulins with the presence of CAE underlines the divergent features of pathophysiology of CAE compared with atherosclerosis or CAD alone. Comparable activity of humoral immunity measured by IgG antibody against C.Pneumoniae, and H. Pylori has suggested that these infectious agents do not play an additional role in the pathogenesis of CAE. © 2025 Cardiological Society of India
dc.identifier.doi10.1016/j.ihj.2025.09.004
dc.identifier.issn0019-4832
dc.identifier.scopus2-s2.0-105017245379
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.ihj.2025.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10497
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofIndian Heart Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260128
dc.subjectAlpha 2 macroglobulin
dc.subjectAtherosclerosis
dc.subjectBeta-1 globulin
dc.subjectChlamydia pneumonia
dc.subjectCoronary artery ectasia
dc.subjectHelicobacter pylori
dc.subjectIgE
dc.subjectMolecular biology
dc.subjectProtein electrophoresis
dc.titleInfectious agents, protein electrophoresis and immunoglobulin levels in patients with coronary artery ectasia
dc.typeArticle

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