Isolated Optic Neuritis and Definite Multiple Sclerosis Conversion Features

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dc.contributor.authorGençdal, Işıl Yazıcı
dc.contributor.authorÖzdemir, Gülten
dc.contributor.authorAgaoglu, Jale
dc.contributor.authorÖrken, Cihat
dc.contributor.authorTanık, Osman
dc.date.accessioned2025-03-09T10:53:36Z
dc.date.available2025-03-09T10:53:36Z
dc.date.issued2024
dc.departmentİstanbul Beykent Üniversitesi
dc.description.abstractObjective: Identifying the factors associated with the development of multiple sclerosis (MS) in isolated optic neuritis (ION) is vital for early treatment decisions. Materials and Methods: In this study, we investigated definite MS conversion properties in patients with ION based on neurological, laboratory, magnetic resonance imaging (MRI), visual evoked potential (VEP), cerebrospinal fluid (CSF) examinations according to McDonald criteria 2005 and 2017. Results: Twenty-six of 41 patients (63.4%) with ION developed definite MS according to McDonald criteria 2005, and 32 patients (78%) developed it according to McDonald criteria 2017. We found that the risk of MS development after ION increased in the first 2 years (34.1%) according to McDonald Criteria 2005. VEP examinations revealed that prolonged latency in the P100 response supported the MS diagnosis. In the cranial MRI, the presence and excessiveness of white matter lesions were critical factors in predicting conversion from ON to MS. In addition, oligoclonal band (OCB) detection in the CSF helps predict MS conversion. Conclusion: Identifying the prognostic factors to understand MS development in ION and other clinically isolated syndromes (CIS) is essential when selecting patients for early treatment and considering early treatment options. The 2017 McDonald criteria provide a more rapid diagnosis of MS, but atypical clinical manifestations and misleading MRI findings must be carefully considered.
dc.identifier.doi10.14744/cm.2024.63644
dc.identifier.endpage111
dc.identifier.issn2822-6771
dc.identifier.issue2
dc.identifier.startpage106
dc.identifier.trdizinid1274718
dc.identifier.urihttps://doi.org/10.14744/cm.2024.63644
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1274718
dc.identifier.urihttps://hdl.handle.net/20.500.12662/4864
dc.identifier.volume16
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofComprehensive medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR_20250310
dc.subjectMultiple sclerosis
dc.subjectoptic neuritis
dc.subjectoligoclonal band
dc.titleIsolated Optic Neuritis and Definite Multiple Sclerosis Conversion Features
dc.typeArticle

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