Effects of Silica Nanoparticle Administration on Testis Structure

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dc.contributor.authorDeveci, Serkan
dc.contributor.authorElmas, Merve Açıkel
dc.contributor.authorYücel, Deniz
dc.contributor.authorKeskin, Mehmet Selçuk
dc.contributor.authorDelipınar, Sibel Demirci
dc.contributor.authorÖzakpınar, Özlem Bingöl
dc.contributor.authorSeçkin, İsmail
dc.date.accessioned2026-01-31T14:59:04Z
dc.date.available2026-01-31T14:59:04Z
dc.date.issued2025
dc.departmentİstanbul Beykent Üniversitesi
dc.descriptionTUBITAK, PROJECT NUMBER: 215S642
dc.description.abstractObjective: This study aimed to investigate the effects of oral and local application of silica-based nanoparticles on spermatogenesis. The study also investigated the potential toxic effects of silica-based local and systemic applied nanoparticles on spermatogenesis, which will be used as a different delivery system in our future studies. Materials and Methods: Sprague-Dawley male rats were randomly divided into 3 groups: control group, local silica nanoparticle-administered group (L group), and oral silica-administered group (G group). Gavage group rats were administrated with oral silica nanoparticles, and the local group rats were topically administrated with local silica nanoparticles of 2 mg/cm². The testicular samples were prepared for light and electron microscopic analysis at the end of the experiment. The total antioxidant status (TAS) and total oxidant status (TOS) were measured in the blood serum. Results: Normal testis morphology was observed in the control group. Seminiferous tubules were more disrupted in the G group compared with the L group. Serum TAS levels were increased in the L group compared with the G group. Degenerated testis morphology, increased TOS levels, and decreased occludin immunoreactivity were observed in the G group. These morphological and biochemical parameters were reduced in the L group. Conclusion: This study showed that oral administration of silica-based nanoparticles increased tissue damage and antioxidant levels. Local administration protected the testis tissue damage compared with oral administration by modulating the oxidant/antioxidant balance.
dc.description.sponsorshipThis study was supported by TÜBİTAK (Scientific and Technological Research Council of Turkey) (PROJECT NUMBER 215S642, YEAR: 2016).
dc.identifier.doi10.26650/EurJBiol.2025.1554636
dc.identifier.endpage198
dc.identifier.issn2602-2575
dc.identifier.issn2618-6144
dc.identifier.issue2
dc.identifier.startpage189
dc.identifier.urihttps://doi.org/10.26650/EurJBiol.2025.1554636
dc.identifier.urihttps://hdl.handle.net/20.500.12662/10224
dc.identifier.volume84
dc.language.isoen
dc.publisherİstanbul Üniversitesi
dc.publisherIstanbul University
dc.relation.ispartofEuropean Journal of Biology
dc.relation.ispartofEuropean Journal of Biology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260128
dc.subjectCell Development
dc.subjectProliferation and Death
dc.subjectHücre Gelişimi
dc.subjectProliferasyon ve Ölümü
dc.subjectBiochemistry and Cell Biology (Other)
dc.subjectBiyokimya ve Hücre Biyolojisi (Diğer)
dc.titleEffects of Silica Nanoparticle Administration on Testis Structure
dc.typeArticle

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