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    Determination of relationship between lipid peroxidation, antioxidant defence, trace elements, and hemorheology in COPD
    (Dustri-Verlag Dr Karl Feistle, 2019) Saribal, Devrim; Hocaoglu-Emre, Fatma Sinem; Aydemir, Birsen; Akyolcu, Mehmet Can
    Background and objective: Oxidative stress has an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). There are studies suggesting a role of increased oxidative stress and decreased antioxidants in COPD patients. The aim of this study was to assess the levels of oxidative and anti-oxidant system elements, serum concentrations of trace elements, and blood viscosity in COPD patients. Materials and methods: Our study group consisted of 25 male patients with COPD, and 25 healthy non-smokers. The lipid peroxidation product malondialdehyde (MDA) and the anti-oxidant system elements superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were measured spectrophotometrically. Serum concentrations of copper (Cu), zinc (Zn), and iron (Fe) were determined using an atomic absorption spectrophotometer. Additionally, we measured blood viscosity using a viscosimeter. Results: Lipid peroxidation product MDA levels were found to be higher in plasma and erythrocytes. However GSH levels, SOD, and CAT enzyme activities were lower in erythrocytes of the patient group than in controls (p < 0.01). Fe and Zn levels were decreased, whereas Cu levels were increased in patient samples (p < 0.05. p < 0.01, respectively). There was no statistically significant difference between plasma and blood viscosities. Conclusion: The results of this study indicate that COPD leads to lipid peroxidation in the erythrocyte membrane and to decreased levels of anti-oxidant system elements. Serum trace element concentrations were found to be altered in COPD patients, suggesting their interaction with oxidant and anti-oxidant enzymes.
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    Effects of the oxidative stress and genetic changes in varicose vein patients
    (Sage Publications Inc, 2019) Saribal, Devrim; Kanber, Eyup Murat; Hocaoglu-Emre, Fatma Sinem; Akyolcu, Mehmet C.
    Background Etiology of the varicose veins is still partly known. It has been proposed that varicose veins formation might be a cause of the oxidative stress and/or cause from genetical reasons. Method The levels of antioxidant defense system enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and an oxidative stress indicator, malondialdehyde, were measured in saphenous vein samples of varicose veins patients. Additionally, genetical polymorphism of glutathione S-transferase theta-1 has been studied. Result In this study, measurements revealed significant increase in catalase and malondialdehyde levels in the patient group, whereas superoxide dismutase and glutathione peroxidase and glutathione S-transferase enzyme activity and comparison of the null mutation frequency in the glutathione S-transferase theta-1 gene did not show a statistically significant difference. Conclusion We propose that the increase in catalase and malondialdehyde activities in our patient group may be related to each other. Increase in catalase levels, an antioxidant enzyme might be a compensatory response to the increase in malondialdehyde levels, an oxidative molecule.
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    Metformin decreases testicular damages following ischaemia/reperfusion injury in rats
    (Wiley, 2020) Saribal, Devrim; Erdem, Erkan; Gungor-Ordueri, Nazli Ece; Usta, Akin; Karakus, Cemil; Karacan, Meric
    The effects of metformin on a testicular torsion injury in adolescent rat testis after I/R were evaluated in the present study. Forty adolescent rats were divided into five groups with eight rats per group: a control group; a sham-operated group; an ischaemia group, where torsion was applied for 4 hr and testis was examined immediately after detorsion; an I/R group, where torsion was applied for 4 hr and the testis was examined 4 hr after detorsion; and an I/R + M group, where the metformin (300 mg/kg) administration was added to the identical procedures used for the I/R group. Spermatogenesis, basal membrane integrity and cleaved caspase-3 expression were assessed. The I/R + M group had a significantly higher Johnsen score than the I/R group (7.9 +/- 0.1 vs. 7.5 +/- 0.2; p F-value = 14.2). Failure of basal membrane integrity was highest in the ischaemia group (45 +/- 5) compared to the other groups (control group, 20 +/- 5; sham-operated group, 16.6 +/- 2.8), but not different between the I/R + M (31.6 +/- 12.5) and the I/R groups (25 +/- 3.5). Cleaved caspase-3 expression was highest in the ischaemia group (73.5 +/- 0.7), and significantly lower in the I/R + M group (33.4 +/- 0.9) than the I/R group (58.5 +/- 0.2; p F-value = 7.6). Metformin decreases testicular damage by exerting protection against the harmful effects of I/R on spermatogenesis and alleviating apoptosis in adolescent rat testis.
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    Trace Element Levels and Oxidant/Antioxidant Status in Patients with Alcohol Abuse
    (Humana Press Inc, 2020) Saribal, Devrim; Hocaoglu-Emre, Fatma Sinem; Karaman, Fulya; Mirsal, Hasan; Akyolcu, Mehmet Can
    Alcohol abuse is a well-known cause of imbalance in trace element levels and oxidant/antioxidant status of individuals with long time consumption. However, the levels of these parameters in the patients on the early stages of alcohol dependence without liver damage differ on various studies. The aim of our study was to measure the levels of trace elements in the serum and oxidative/antioxidative system members in the red blood cells (RBC) of early-stage alcoholic individuals and compare with control subjects. Our study included 21 male patients recently hospitalized for alcohol abuse and 25 healthy non-abusing male controls. Levels of Fe, Zn, and Cu in the serum and MDA, SOD, CAT, and GSH in the red blood cells (RBC) of the subjects were measured. Fe, Zn, and Cu levels were lower in the study group when compared to the controls. Levels of lipid peroxidation marker MDA was high, whereas the activities of antioxidant enzymes SOD and CAT were decreased in our study group. However, levels of GSH, an antioxidant compound were higher in the alcohol abuse group. RBC SOD levels were positively correlated with Fe, Cu, Zn, and CAT. There was a positive correlation between Fe-Cu, Zn-Fe, Zn-Cu, CAT-Zn, and CAT-SOD. MDA was negatively correlated with Fe, Zn, SOD, and CAT. The results obtained from present study indicate that high levels of alcohol intake are related with increased oxidative damage and decreased levels of antioxidant enzymes and trace elements. Additionally, antioxidant compensation mechanisms are still on process in the early stages of chronic alcohol exposure.