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Öğe Antimicrobial, anti-biofouling, antioxidant, and biocompatible fabrics with high durability via green growth of trimetallic nanoparticles(Elsevier, 2024) Sahin, Gamze Demirel; Sahin, Furkan; Barlas, Firat Baris; Onses, Mustafa Serdar; Acar, SerapThere is a high demand for green and sustainable multifunctional fabrics, which find application in a variety of real-life contexts. This study addresses the development of antimicrobial, antioxidant, anti-biofouling and biocompatible fabrics through a one-step, versatile and cost-effective in-situ green growth strategy. Monometallic, bimetallic and trimetallic nanoparticles comprising silver (Ag), copper (Cu) and zinc (Zn) were grown in-situ on fabric surfaces using Sideritis scardica extract. The average size of nanoparticles was 99 +/- 25 nm, 131 +/- 29 nm, 68 +/- 18 nm for Ag, Cu and Zn. The metallic nanoparticles grown on the fabric surface imparted a range of colors to the fabrics, including yellow, brownish and greenish hues. Nanoparticle-decorated fabrics have antimicrobial, antioxidant, anti-biofouling, biocompatibility, and high durability properties. The decoration of fabrics with metallic nanoparticles mediated antimicrobial properties against bacteria (E. coli and S. aureus) and fungi (C. albicans), achieving a reduction of over 99.99 % (Logarithmic reduction>4). Bimetallic and trimetallic Ag and Cu nanoparticles exhibited enhanced antifungal activity in comparison to their monometallic counterparts. The cytotoxic effects of Cu were effectively eliminated through the fabrication of bimetallic nanostructures containing Zn. Notably, the biocompatibility of monometallic and bimetallic combinations involving Ag and Zn exceeded 95 %. The water contact angles of the decorated fabrics ranged from 145 degrees to 153 degrees. The superhydrophobic character of the fabrics prevented pathogen adhesion and inhibited biofilm formation. Moreover, all nanoparticle-decorated fabrics demonstrated antioxidant properties, with radical-scavenging activity ranging from 46 % to 91 %. The fabrics retained their antimicrobial properties against mechanical abrasion, heating and repeated cycles of washing and bending.Öğe Fabrication and Characterization of Amphotericin B Loaded Poly(Vinyl Alcohol)/Chitosan-ZnO Biocomposite Films for Antimicrobial Wound Dressings(Wiley, 2025) Tosyali, Ozlem Ayse; Sahin, Furkan; Cetin, Yuksel; Karal-Yilmaz, OksanDeveloping efficient hydrogel-based wound dressings has gained increasing attention in improved wound healing capabilities. In this study, the biocomposite hydrogel films consisting of polyvinyl alcohol (PVA), chitosan (CS), and zinc oxide nanoparticles (ZnO NPs) were prepared using the solvent casting method. The biocomposite hydrogel films were also loaded (5% w/w) with Amphotericin B (AmB) as a model drug to develop a new suitable material with potential application as high-performance wound dressing with controlled drug release. The chemical nature, thermal properties, and morphology of the PVA/CS and PVA/CS-ZnO biocomposite hydrogels were analyzed and compared by FTIR, TGA, and SEM-EDX analysis. The effect of ZnO NPs on swelling behavior in the PVA/CS films was studied. PVA/CS-ZnO biocomposite hydrogels presented a lesser degree of swelling compared to ZnO-free hydrogels. The AmB-loaded hydrogel films exhibited a sustained release rate during 72 h in PBS at pH 7.4. Biocompatibility of all hydrogel types (with or without ZnO and AmB) using L929 and HaCaT cell lines was evaluated with high cell viability examined by MTT assay. The antimicrobial activity of the films was evaluated against Escherichia coli, Staphylococcus aureus, and Candida albicans using a modified AATCC 100 method, whereby the R value represents the log reduction in the number of surviving colonies. The mean R values for drug-free PVA/CS-ZnO hydrogel films were 6.81 for E. coli, 6.03 for S. aureus, and 6.82 for C. albicans. The addition of AmB further enhanced the antimicrobial activity, increasing the R values for E. coli to 7.16, for S. aureus to 6.38, and for C. albicans to 7.31, demonstrating a significant synergistic effect with maximum antimicrobial efficacy. The results showed that the AmB-loaded biocomposite hydrogel films (PVA/CS-ZnO-AmB) can be used as a new wound dressing material.Öğe Food-Grade Physically Unclonable Functions(Amer Chemical Soc, 2023) Esidir, Abidin; Kayaci, Nilgun; Kiremitler, N. Burak; Kalay, Mustafa; Sahin, Furkan; Sezer, Gulay; Kaya, MuratCounterfeit products in the pharmaceutical and food industries have posed an overwhelmingly increasing threat to the health of individuals and societies. An effective approach to prevent counterfeiting is the attachment of security labels directly on drugs and food products. This approach requires the development of security labels composed of safely digestible materials. In this study, we present the fabrication of security labels entirely based on the use of food-grade materials. The key idea proposed in this study is the exploitation of food-grade corn starch (CS) as an encoding material based on the microscopic dimensions, particulate structure, and adsorbent characteristics. The strong adsorption of a food colorant, erythrosine B (ErB), onto CS results in fluorescent CS@ErB microparticles. Randomly positioned CS@ErB particles can be obtained simply by spin-coating from aqueous solutions of tuned concentrations followed by transfer to an edible gelatin film. The optical and fluorescence microscopy images of randomly positioned particles are then used to construct keys for a physically unclonable function (PUF)-based security label. The performance of PUFs evaluated by uniformity, uniqueness, and randomness analysis demonstrates the strong promise of this platform. The biocompatibility of the fabricated PUFs is confirmed with assays using murine fibroblast cells. The extremely low-cost and sustainable security primitives fabricated from off-the-shelf food materials offer new routes in the fight against counterfeiting.Öğe Mechanochemical Activation of Silicone for Large-Scale Fabrication of Anti-Biofouling Liquid-like Surfaces(Amer Chemical Soc, 2023) Celik, Nusret; Sahin, Furkan; Ruzi, Mahmut; Ceylan, Ahmet; Butt, Hans-Jurgen; Onses, Mustafa SerdarLarge-scale preparation of liquid-like coatings with perfect transparency via solventless and room-temperature processes using low-cost and biocompatible materials is of tremendous interest for a broad range of applications. Here, we present a mechanochemical activation strategy for solventless grafting of poly-(dimethylsiloxane) (PDMS) onto glass, silicon wafers, and ceramics. Activation is achieved via ball milling PDMS without using any solvents or additives prior to application. Ball milling results in chain scission and generation of free radicals, allowing room-temperature grafting at durations <= 1 h. The deposition of ball-milled PDMS can be facilitated by brushing or drop-casting, enabling large-scale applications. The resulting surfaces facilitate the sliding of droplets at angles <20(degrees) for liquids with surface tension ranging from 22 to 73 mN/m. An important application for public health is generating anti-biofouling coatings on sanitary ware. For example, PDMS-grafted surfaces prepared on a regular-size toilet bowl exhibit a 105-fold decrease in the attachment of bacteria from urine. These findings highlight the significant potential of mechanochemical processes for the practical preparation of liquid-like surfaces.Öğe Mechanochemical Coupling of Alkylsilanes to Nanoparticles for Solvent-Free and Rapid Fabrication of Superhydrophobic Materials(Amer Chemical Soc, 2023) Celik, Nusret; Sezen, Berk; Sahin, Furkan; Ceylan, Ahmet; Ruzi, Mahmut; Onses, Mustafa SerdarExcellent repellencytoward water is one of the main characteristicsof superhydrophobic coatings that endow application potential in variousareas. However, the complex and time-consuming process involved inpreparing universally applicable superhydrophobic coatings, especiallythe step that involves modifying intrinsically hydrophilic inorganicoxide nanoparticles with hydrophobic alkylsilanes, limits their practicalapplications. This study demonstrates a rapid and eco-friendly approachto preparing superhydrophobic surfaces by chemically grafting alkylsilanemolecules onto silica nanoparticles using a mechanochemical process.The key advantages of this approach are (i) rapid process with preparationtimes that are orders of magnitude shorter than those of conventionalmethods, (ii) zero-solvent usage, and (iii) overcoming the need fortedious separation and drying steps. The resultant surface exhibitssuperhydrophobicity with a water contact angle of 172 & DEG; and asliding angle of 1 & DEG;. A monolith prepared by compressing the powderexhibits superhydrophobicity, durability, and antifouling abilityagainst urine. The superhydrophobic surface inhibits the growth oftwo of the most common pathogenic bacteria. The bacterial growth wasreduced by 10(7.07) for Escherichia coli and 10(5.78) for Staphylococcus aureus. The proposed approach is practical, swift, and cost-effective,making it a scalable and eco-friendly technique for the solvent-freepreparation of superhydrophobic surfaces.Öğe Nanostructured Surfaces with Plasmonic Activity and Superhydrophobicity: Review of Fabrication Strategies and Applications(Wiley-V C H Verlag Gmbh, 2025) Ruzi, Mahmut; Celik, Nusret; Sahin, Furkan; Sakir, Menekse; Onses, M. SerdarPlasmonics and superhydrophobicity have garnered broad interest from academics and industry alike, spanning fundamental scientific inquiry and practical technological applications. Plasmonic activity and superhydrophobicity rely heavily on nanostructured surfaces, providing opportunities for their mutually beneficial integration. Engineering surfaces at microscopic and nanoscopic length scales is necessary to achieve superhydrophobicity and plasmonic activity. However, the dissimilar surface energies of materials commonly used in fabricating plasmonic and superhydrophobic surfaces and different length scales pose various challenges to harnessing their properties in synergy. In this review, an overview of various techniques and materials that researchers have developed over the years to overcome this challenge is provided. The underlying mechanisms of both plasmonics and superhydrophobicity are first overviewed. Next, a general classification scheme is introduced for strategies to achieve plasmonic and superhydrophobic properties. Following that, applications of multifunctional plasmonic and superhydrophobic surfaces are presented. Lastly, a future perspective is presented, highlighting shortcomings, and opportunities for new directions.Öğe Practical SERS substrates by spray coating of silver solutions for deep learning-assisted sensitive antigen identification(Elsevier B.V., 2025) Sahin, Furkan; Demirel Sahin, Gamze; Camdal, Ali; Akmayan, Ilkgul; Ozbek, Tulin; Acar, Serap; Onses, Mustafa SerdarSurface-enhanced Raman spectroscopy (SERS) has long been recognized for its rapid and sensitive detection capabilities; however, challenges persist in practical fabrication of the substrates and interpreting complex data. Herein, we propose a deep learning (DL) assisted SERS approach to enable rapid and sensitive detection of analytes on practical yet highly effective substrates prepared by direct spray-coating of a nanoparticle-free true solution of a reactive Ag ink and on-site thermal annealing mediated generation of nanostructures. This design ensured homogeneous distribution of Ag nanostructures throughout the entire substrate, significantly increasing the number of hotspots and enhancing the Raman signals, thereby achieving an impressive analytical enhancement factor of ∼1010 in a reproducible and consistent manner. The diagnostic utility of this platform was demonstrated by detecting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in both buffer and saliva, with detection limits of 74.3 pg/mL and 7.43 ng/mL, respectively. The DL-assisted SERS not only accurately identified the presence or absence of viral antigen, but also automatically quantified the viral load. This automatic identification achieved an outstanding accuracy of ∼99.9 %, highlighting the exceptional performance of the proposed platform. This simple, cost-effective, scalable, and ultra-sensitive DL-assisted SERS platform offers significant opportunities for early and precise detection in a range of analytical scenarios. © 2024 Elsevier B.V.Öğe Tattoo-Like Multi-Color Physically Unclonable Functions(Wiley-V C H Verlag Gmbh, 2023) Kiremitler, N. Burak; Esidir, Abidin; Drake, Gryphon A.; Yazici, Ahmet Faruk; Sahin, Furkan; Torun, Ilker; Kalay, MustafaAdvanced anti-counterfeiting and authentication approaches are in urgent need of the rapidly digitizing society. Physically unclonable functions (PUFs) attract significant attention as a new-generation security primitive. The challenge is design and generation of multi-color PUFs that can be universally applicable to objects of varied composition, geometry, and rigidity. Herein, tattoo-like multi-color fluorescent PUFs are proposed and demonstrated. Multi-channel optical responses are created by electrospraying of polymers that contain semiconductor nanocrystals with precisely defined photoluminescence. The universality of this approach enables the use of dot and dot-in-rod geometries with unique optical characteristics. The fabricated multi-color PUFs are then transferred to a target object by using a temporary tattoo approach. Digitized keys generated from the red, green and blue fluorescence channels facilitate large encoding capacity and rapid authentication. Feature matching algorithms complement the authentication by direct image comparison, effectively alleviating constraints associated with imaging conditions. The strategy that paves the way for the development of practical, cost-effective, and secure anticounterfeiting systems is presented. Tattoo-like multi-color encoding layers based on random processing of semiconductor nanocrystals of varied composition and geometry are reported. Additive deposition via chaotic electrospraying enables randomness and multiplexing, whereas the tattoo approach provides substrate independence.image
