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Öğe EVALUATION OF ZINC AND COPPER TOXICITY CAUSED BY INGESTION OF TURKISH COINS: AN IN VITRO STUDY(Polish Society Magnesium Research, 2020) Alkan, Fatma Ates; Kilinc, Evren; Gulyasar, Tevfik; Or, Mehmet ErmanCoins are foreign objects that are commonly ingested by children and pets due to their shiny appearance and bright colors. The current study investigated whether Turkish coins can lead to zinc (Zn) and copper (Cu) toxicity as a result of exposure to simulated gastric juice (i.e. hydrochloric acid solution simulating the gastric environment). Five groups of coins were exposed to simulated gastric juice (0.15 N, pH:1-2) for a period of 4 (Group 1), 12 (Group 2), 24 (Group 3), 48 (Group 4), 72 (Group 5) and 120 h (Group 5) at body temp. (37 degrees C). Zinc and copper levels were determined in the gastric acid solution by using an inductively coupled plasma optical emission spectrophotometer (ICP-OES). The coins were also evaluated for corrosive damage and weight loss. Group 5 had statistically higher Cu and Zn levels versus the other groups. However, at body temp. (37 degrees C), copper and zinc levels increased steadily in parallel to the duration for which the coin remained in the stomach after ingestion. After 120-hour exposure at 37 degrees C, all coins had various types of damage compared to the baseline, such as color alteration, erosion, and visible surface cavities. The mechanisms relating to local and systemic copper and zinc toxicity caused by coin ingestion is yet to be clarified for both Turkish and international coins. Therefore, it can be foreseen that intervention is required in the first 24 h after ingesting 5 kurus coins and, unless removed spontaneously in 48 h, such intervention is needed for the other coins.Öğe Investigation of the Relationship Between Q-Fever Seropositivity and Trace Element Levels in Dairy Cattle(Kocatepe Veterinary Journal, 2021) Alkan, Fatma Ateş; Mavili, Zehra Seda; Dokuzeylül, Banu; Yaramış, Çağla Parkan; İkiz, Serkan; Saka, Sinem Ülgen; Or, Mehmet ErmanQuery fever (Q fever) which is caused by Coxiella burnetii is a continuing problem as a zoonotic disease in the world. In ruminants, infections are mostly asymptomatic however, abortions and stillbirths may occur during late pregnancy. Trace elements are important for the reproductive performance of ruminants and all have roles in immune function. However, serum trace element levels of Coxiella seropositive infertile and healthy dairy cows have not been investigated yet. The present was aimed to evaluate the trace element status of cattle associated with Coxiella burnetii. For this purpose, 200 dairy cattle with and without clinical problems (infertility, metritis and abortion) were compared. Q fever infection was confirmed with ELISA. Levels of trace elements of samples were analysed utilizing inductively coupled plasma-optical emission spectrophotometer. Serum levels of trace elements of the samples were expressed as ?g/mL. In total, 20 of 200 sera were diagnosed to be positive by ELISA. Nine of 20 sera were positive from asymptomatic cattle. Seven of 11 sera were positive from cattle with infertility, while 4 of 11 sera were positive from cattle with abortion. No significant differences were found between trace element levels of ELISA seropositive cattle and asymptomatic seropositive cattle. In conclusion, although statistical analysis of serum trace elements is no significant, our findings clearly show that analysis of trace element levels in cattle may be useful predictors in early treatment and prognosis. Further studies are required to clarify the connection between Coxiella seropositivity, trace elements and clinical symptoms in cattle.Öğe Sistemik Aspergillosis Ve Kandidiyazisin Tedavisinde Ekinokandin Grubu Antimikotiklerin Etkinliği Ve Veteriner Hekimliğindeki Yeri(Journal of Advances in VetBio Science and Techniques, 2018) Ates Alkan, Fatma; Nasiboglu, Belgi; Dokuzeylul, Banu; Barutcu, Umit Bora; Or, Mehmet Ermanİnsan ve hayvan sağlığı açısından fungal hastalıklar büyük sorun yaratmaktadır. Bu nedenle son kırk yılda pek çok antifungal üretilmiş ve sağlık alanında kullanıma başlanmıştır. İlaçların kullanımı ile birlikte dirençli mantar etkenlerinin ortaya çıkması sık kullanılan antimikotiklerin yerine alternatif ilaçların üretilmesini zorunlu kılmıştır. Bu derlemede, sistemik mikozlardan Candida spp. ve Aspergillus spp. tedavisinde uzun süredir kullanılan, polien ve azol grubu antifungallere alternatif olarak; veteriner hekimlikte ekinokandin grubu ilaçların kullanımının arttırılması yönünde bilinç uyandırmak amaçlanmıştır.