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    Amounts of tissue magnesium and some trace elements in cats with mammary tumors related to various clinicopathological parameters
    (Elsevier Gmbh, 2023) Ucmak, Zeynep Gunay; Koenhemsi, Lora; Ates, Fatma; Tarhan, Duygu; Gurgen, Hazal Ozturk; Yildirim, Funda; Ucmak, Melih
    Background: Mammary tumors are one of the major malignancies seen in cats. Researchers have indicated the similarity between the epidemiological and clinicopathological patterns of feline mammary tumors and human breast cancer (HBC). In recent years, the investigation of trace elements in cancer tissues becomes prevalent in HBC due to the role of these elements in biochemical and physiological processes. This study, it is aimed to evaluate some trace elements in feline mammary tumors according to clinical and pathological findings.Methods: A total of 60 tumoral masses from 16 female cats with mammary tumors were included in the study. The study groups were formed according to histopathology as malignant epithelial tumor (MET; n = 39) and hy-perplasia and dysplasia (H & D; n = 21). Copper (Cu), Iron (Fe), Magnesium (Mg), Manganese (Mn), Selenium (Se) and Zinc (Zn) trace elements in mammary tissues were analyzed by using an inductively coupled plasma-optical emission spectrophotometer.Results: The mean age and weight of the cats were 11.75 & PLUSMN; 0.75 years and 3.35 & PLUSMN; 0.21 kg; respectively. Eleven of 16 cats were intact whereas the rest of them had been spayed. Metastases were observed in 10 cats. Tissue Mg level in group MET was significantly higher than in group H & D (P < 0.01) while the other elements had not significant differences between the groups. In group MET, analyzed elements were not statistically significant related to the inflammation, ulceration and invasion to the peripheral muscle (P > 0.05). However, tissue Fe level was significantly higher in T2 than in T3 (P < 0.05). The mean levels of tissue Fe, Mg and Mn had significant differences related to histological grading as P < 0.01, P < 0.05 and P < 0.001; respectively. A mild to severe correlation was found between tissue Zn and Se, Cu, Fe, Mg, and Mn levels.Conclusion: Tissue Mg and some trace elements were evaluated in feline mammary tumours in regard to various clinicopathological parameters. Tissue Mg level was sufficient to differentiate the malignant epithelial tumors from hyperplasia and dysplasia. However, Mn and Se tended to distinguish different tumor types. Tissue Fe, Mg and Mn had significant differences related to histological grading. Also, the Fe level was significantly higher in T2 than in T3 and Zn level tended to be higher in T3 than in T1. It was concluded that Mg, Se, Mn, Fe, Cu and Zn provided useful information on the pathogenesis of feline mammary tumors. Further research is needed on the tissue and serum concentrations of trace elements which may provide valuable information for the disease prognosis.
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    Evaluation Of Trace Elements İn Equine Piroplasmosis
    (Oficyna Wydawnicza, 2019) Koenhemsi, Lora; Ateş Alkan, Fatma; Morganti, Giulia; Barutçu, Ümit Bora; OR, Mehmet Erman
    Equine piroplasmosis (EP) is a tick-borne disease caused by Babesia caballi and Theileria equi, which causes a significant economic loss. The aim of this study was to determine the disease-related changes of serum trace elements that play an important role in the immune system. Our study was conducted on 20 horses with piroplasmosis and 20 healthy horses. It was performed to evaluate some of the serum trace element levels (chromium (Cr), copper (Cu), iron (Fe), magnesium (Mg) manganese (Mn), selenium (Se), zinc (Zn), arsenic (As), boron (B), and nickel (Ni)) in equine piroplasmosis. The elements were analyzed in serum using ICP-OES. Infected horses had significantly higher serum Mg and Mn levels. In conclusion, changes of serum trace elements in infected horses can provide valuable information about pathophysiological aspects and they are also good indicators for diagnosis, prognosis and treatment evaluation. Much more scientific research is required to evaluate the trace elements related to equine piroplasmosis