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    Impact of trophoectoderm biopsy for preimplantation genetic testing on serum ß-hCG levels, time of delivery and birthweight following frozen embryo transfer cycles
    (Taylor & Francis Ltd, 2023) Ozdamar, Ozkan; Boynukalin, F. Kubra; Gultomruk, Meral; Yarkiner, Zalihe; Findikli, Necati; Bahceci, Mustafa
    Aim: This study investigated whether trophoectoderm (TE) biopsy adversely impacts serum ss-human chorionic gonadotropin (hCG) level on the 15th day of embryo transfer (ET), delivery week and birthweight, between biopsied and unbiopsied embryo groups, in a cohort of women who delivered a singleton baby, following frozen-thawed ET. Methods: All women having had a live birth after blastocyst ET s following frozen ET cycles with preimplantation genetic testing (PGT) were included. A control group was selected among women who had a live birth following single frozen blastocyst transfer without PGT-A at the same period in our clinic Results: One hundred fifteen and 173 cycles with- and without-PGT, respectively, were included. Serum ss-hCG level on the 15th day after ET was comparable between the groups (p =.336). Average birthweight of the babies born following biopsied embryos were significantly lower (3200 vs. 3380; p =.027). Women who received trophectoderm biopsied embryos had a significantly higher probability of having a baby weighing <= 1500 g and 1500-2500 g (p =.022) or <= 2500 g (p =.008). Proportion of preterm delivery was significantly higher in the biopsy group (p =.023). However, after adjusting for potential covariates, trophectoderm biopsy did not seem to increase the risk of preterm birth (OR 1.525; 95% CI, 0,644-3.611; p =.338) Conclusions: TE biopsy does not seem to impact serum ss-hCG level on the 15th day after ET. Average birthweight is lower when a biopsied embryo was transferred. After adjusting for potential covariates, trophectoderm biopsy does not seem to increase the risk of preterm birth
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    Investigating the cryoprotective efficacy of fructans in mammalian cell systems via a structure-functional perspective
    (Elsevier Sci Ltd, 2024) Tornaci, Selay; Erginer, Merve; Gokalsin, Baris; Aysan, Arzu; Cetin, Metin; Sadauki, Mubarak; Findikli, Necati
    Fructans have long been known with their role in protecting organisms against various stress factors due to their ability to induce controlled dehydration and support membrane stability. Considering the vital importance of such features in cryo-technologies, this study aimed to explore the cryoprotective efficacy of fructans in mammalian cell systems where structurally different fructan polymers were examined on in vitro cell models derived from organs such as the liver, frequently used in transplantation, osteoblast, and cord cells, commonly employed in cell banking, as well as human seminal fluids that are of vital importance in assisted reproductive technology. To gain insights into the fructan/membrane interplay, structural differences were linked to rheological properties as well as to lipid membrane interactions where both fluorescein leakage from unilamellar liposomes and membrane integrity of osteoblast cells were monitored. High survival rates obtained with human endothelial, osteoblast and liver cells for up to two months clearly showed that fructans could be considered as effective non-permeating cryoprotectants, especially for extended periods of cryopreservation. In trials with human seminal fluid, short chained levan in combination with human serum albumin and glycerol proved very effective in preserving semen samples across multiple patients without any morphological abnormalities.