Mosaic Human Preimplantation Embryos And Their Developmental Potential İn A Prospective, Non-Selection Clinical Trial
Yükleniyor...
Tarih
2021
Yazarlar
Fındıklı, Necati
.;, ve diğer
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cell Press
Erişim Hakkı
Özet
Chromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos suggest that aneuploidy commonly originates during early divisions, resulting in mosaicism. However, the developmental potential of mosaic embryos remains unclear. We followed the distribution of aneuploid chromosomes across 73 unselected preimplantation embryos and 365 biopsies, sampled from four multifocal trophectoderm (TE) samples and the inner cell mass (ICM). When mosaicism impacted fewer than 50% of cells in one TE biopsy (low-medium mosaicism), only 1% of aneuploidies affected other portions of the embryo. A double-blinded prospective non-selection trial (NCT03673592) showed equivalent live-birth rates and miscarriage rates across 484 euploid, 282 low-grade mosaic, and 131 medium-grade mosaic embryos. No instances of mosaicism or uniparental disomy were detected in the ensuing pregnancies or newborns, and obstetrical and neonatal outcomes were similar between the study groups. Thus, low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.
Açıklama
Anahtar Kelimeler
CHROMOSOMAL MOSAICISM, ANEUPLOIDIES, FERTILITY
Kaynak
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
Sayı
Künye
The American Journal of Human Genetics108, 2238–2247, December 2, 2021
