PubMed İndeksli Yayınlar Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12662/2218

Listeleniyor 1 - 20 / 529

Stroke severity to determine musculoskeletal symptoms in family caregivers
(2023) Sahbaz, Tugba; Medin-Ceylan, Cansın
OBJECTIVE: the objective of this study is to examine the relationship between the musculoskeletal problems experienced by the family members who care for stroke patients, physical health and disability levels. METHOD: the subjects included in the study were patients and family caregivers admitted to the Kanuni Sultan Suleyman Training and Research Hospital Physical Medicine and Rehabilitation outpatient clinic with a stroke diagnosis between May 30 th, 2019, and May 30 th, 2021. The caregivers were assessed using the Extended Nordic Musculoskeletal Questionnaire. Validated scales were employed to evaluate stroke patients' physical health and disability level. RESULTS: a total of 104 stroke patients and 104 caregivers who met our inclusion criteria took part in this study. Low back complaints in the last month were associated with the patients' Functional Ambulation Score (FAS), Functional Independence Measure (FIM), Stroke Impact Scale (SIS) and Brunnstrom scores. Neck pain was the second musculoskeletal complaint, but was not statistically associated with patient-related factors. Upper limb problems were associated with FAS, FIM, SIS, Brunnstrom and the Modified Ashworth Scale scores. CONCLUSION: according to our findings, the low back is the body area most affected by musculoskeletal complaints in family caregivers of stroke patients, closely related to the patients' functional capacity and disability levels. CLINICAL TRIALS NUMBER: NCT04901637 (1) Stroke survivors highly depend on informal caregivers for daily living. (2) Family caregivers are at an increased risk of experiencing musculoskeletal problems. (3) The caregivers' musculoskeletal symptoms are related to the level of the patient disability. (4) Preventive medicine should become a part of nursing education for family caregivers.; OBJETIVO: o objetivo deste estudo é examinar a relação entre os problemas musculoesqueléticos vivenciados pelos familiares que cuidam de pacientes com AVC, a saúde física e o nível de deficiência do paciente.Método:foram incluídos no estudo pacientes e familiares cuidadores admitidos no hospital Kanuni Sultan Suleyman com diagnóstico de AVC entre 30 de maio de 2019 e 30 de maio de 2021. Os cuidadores foram avaliados utilizando o questionário Extended Nordic Musculoskeletal Questionnaire. Escalas validadas foram usadas para avaliar a saúde física e o grau de incapacidade dos pacientes com AVC. RESULTADOS: um total de 104 pacientes com AVC e 104 cuidadores atenderam aos critérios de inclusão do estudo. As queixas lombares no último mês foram associadas aos escores do Functional Ambulation Score (FAS), Functional Independence Measure (FIM), Stroke Impact Scale (SIS) e teste de Brunnstrom do paciente. A dor no pescoço foi a segunda queixa musculoesquelética, mas não foi estatisticamente associada a fatores relacionados ao paciente. Os problemas nas extremidades superiores foram associados aos escores FAS, FIM, SIS, Brunnstrom e à Modified Ashworth Scale. Conclusão:e acordo com os nossos achados, a região lombar é a área do corpo mais afetada por queixas musculoesqueléticas nos cuidadores familiares de pacientes com AVC, que estão intimamente relacionadas ao nível de capacidade funcional e ao grau de incapacidade dos pacientes. Número do estudo clínico: NCT04901637.; (1) Los sobrevivientes de accidentes cerebrovasculares dependen en gran medida de cuidadores informales para la vida diaria. (2) Los cuidadores familiares presentan mayor riesgo de sufrir problemas osteomusculares. (3) Los síntomas osteomusculares de los cuidadores están relacionados con el grado de discapacidad de los pacientes. (4) La medicina preventiva debería pasar a ser parte de la instrucción en Enfermería para cuidadores familiares.; OBJETIVO: el objetivo de este estudio es examinar la relación entre los problemas osteomusculares sufridos por cuidadores familiares que tienen a su cargo velar por pacientes que han sufrido un accidente cerebrovascular y los niveles de salud física y discapacidad.Método:los sujetos incluidos en el estudio eran pacientes y cuidadores familiares atendidos en la clínica de servicios ambulatorios de Fisioterapia y Rehabilitación del Hospital Universitario y de Investigación Kanuni Sultan Suleyman por diagnósticos de ACV entre el 30 de mayo de 2019 y el 30 de mayo de 2021. Los cuidadores fueron evaluados mediante el Extended Nordic Musculoskeletal Questionnaire. Se emplearon escalas validadas para evaluar los niveles de salud física y discapacidad de los sobrevivientes de accidentes cerebrovasculares. RESULTADOS: los participantes de este estudio fueron 104 sobrevivientes de accidentes cerebrovasculares y 104 cuidadores que cumplieron con nuestros criterios de inclusión. Las quejas relacionadas con la región lumbar durante el último mes se asociaron con las puntuaciones obtenidas por los pacientes en el Functional Ambulation Score (FAS), la Functional Independence Measure (FIM) y la Stroke Impact Scale (SIS), además de las puntuaciones Brunnstrom. El dolor de cuello fue la segunda queja osteomuscular, aunque no se asoció estadísticamente con factores relacionados con los pacientes. Los problemas en las extremidades superiores se asociaron con las puntuaciones obtenidas en los instrumentos FAS, FIM, SIS, Brunnstrom y Modified Ashworth Scale. Conclusión:de acuerdo con nuestros hallazgos, la región lumbar es la parte del cuerpo más afectada por quejas osteomusculares en cuidadores familiares de sobrevivientes de accidentes cerebrovasculares, demostrando una estrecha relación con los niveles de capacidad funcional y discapacidad de los pacientes. Número de registro de ensayos clínicos: NCT04901637.
In cases of humeral diaphyseal fractures, is lateral approach surgery without radial nerve exploration as effective and safe as conventional surgery?
(Turkish Association of Trauma and Emergency Surgery, 2024) Doğan, Necati; Hançerli, Cafer Özgür; Büyükdoğan, Halil; Ertürk, Cemil
BACKGROUND: This study compares the efficacy and safety of lateral approach surgery with and without radial nerve dissection in treating humeral diaphyseal fractures. It assesses clinical, radiological, and complication outcomes, providing a description of the surgical methods and perioperative benefits. METHODS: We retrospectively analyzed data from 71 patients admitted between May 2015 and December 2022 who underwent lateral approach surgery for humeral diaphyseal fractures. Group 1, consisting of 34 patients without radial nerve dissection, and Group 2, comprising 37 patients with radial nerve dissection, were compared. Parameters such as age, gender, fracture side (right/ left), fracture type, follow-up time, surgical duration, blood loss, radiological and clinical evaluations (including Shoulder-Elbow range of motion [ROM] and Quick Disabilities of the Arm, Shoulder, and Hand score [Q-DASH]), and complications were examined. Surgical techniques and outcomes were documented. RESULTS: Both groups exhibited comparable distributions in age, gender, fracture types, and follow-up times (p>0.05). Group 1 demonstrated significantly lower surgical duration and blood loss compared to Group 2 (p<0.05 for both). Clinical assessment revealed satisfactory shoulder and elbow ROM within functional limits for all patients, with no instances of infection. Q-DASH scores were similar between groups. Postoperative radial nerve palsy occurred in one patient in Group 1 and three patients in Group 2, with all cases resolving uneventfully during outpatient follow-ups. Radiological assessment confirmed uneventful union in all patients. CONCLUSION: Lateral approach surgery without radial nerve dissection for humeral diaphyseal fractures offers comparable ef-fectiveness and safety to conventional surgery, with potential perioperative advantages such as reduced operation time and blood loss. © 2024, Turkish Association of Trauma and Emergency Surgery. All rights reserved.
Biomechanical effects of different miniplate use on bone and miniplate systems in multiple mandible fracture: A finite element study
(Elsevier Ltd, 2024) Sulukan, Erdinç; Gümrükçü, Zeynep
Purpose: The aim of this study is to evaluate the biomechanical efficiency of different miniplates in the treatment of multiple mandibula fractures. Material and Method: Mandible, miniplates, and screws were modeled using the Solid Works v2015 (Dassault Systèmes, France) program, Subsequently two fracture lines were created on the right parasymphysis and angulus mandible. Models were divided into two main groups according to the plates used in the anterior fracture line: group A, 2 piece 4-hole-bar-I plate, and group B, ellipse plate. Each group was divided into five subgroups according to the plates used in the posterior fracture line (I, X, G, 3D, E) and 10 study models were created in total. Under three different biting forces (anterior, right, left), maximum von-Mises stresses seen on miniplates/screws, and Pmax/Pmin stresses seen in the cortically/cancellous bone were analyzed using the Ansys 16.2 software (ANSYS, Inc., USA). Data was visualized using a color distribution scale and interpreted. Results: The highest von-Mises stress, seen in plates, was found in the I plate (353.82 MPa) at the angulus region of model A1. The highest Pmax and Pmin stresses, revealed in cortical bone, were found respectively in model A1 (181.63 MPa) and model B2 (115.01 MPa). The ideal results on plates were seen in models B3 and B5, in which E plates were used in the parasymphysis and G/E plates were used in the angulus region. Conclusion: Grid and ellipse plates provide successful results and plate geometry is more critical than number in terms of stress distribution. © 2024 Elsevier Ltd
Analyzing the impact of artificial intelligence on operational efficiency in wastewater treatment: a comprehensive neutrosophic AHP-based SWOT analysis
(Springer, 2024) Yalcin, Selin; Ayyildiz, Ertugrul
The escalating global challenges of population growth, climate crisis, and resource depletion have intensified water scarcity, emphasizing the critical role of wastewater treatment (WWT) in environmental preservation. While discharging untreated wastewater poses extinction risks to various species, effective WWT operations are indispensable for ecosystem continuity and sustainable water sources. Recognizing the complexity of WWT management, this study delves into the potential of artificial intelligence (AI) in strategic planning and decision-making within the WWT domain. Through a comprehensive SWOT analysis, this study evaluates the strengths, weaknesses, opportunities, and threats associated with AI integration in WWT processes. Utilizing the SWOT analysis framework, key criteria are identified, and their importance weights are assessed via the interval-valued neutrosophic analytical hierarchy process (IVN-AHP). According to analysis, the strengths in WWT are crucial, but potential opportunities and threats should not be ignored. The results of the study highlight several key findings regarding the integration of AI in WWT processes. While concerns about the reduction in human resources and potential unemployment, as well as the activation time and high energy consumption of AI systems, are identified as significant challenges, the study underscores the success of AI in data analytics as a strong aspect. Specifically, advanced data analysis techniques and the ability to proactively prevent problems emerge as important strengths of AI in WWT. WWT operators and practitioners are encouraged to prioritize the adoption of advanced data analysis techniques and proactive problem-solving strategies to maximize the effectiveness of AI integration in WWT processes. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
Utilization of natural kapok and coconut fiber in thermally insulated sustainable concrete design
(Springer, 2024) Susurluk, Gülşah; Sarikaya, Hakan; Bostanci, Levent
Nowadays, when regenerable alternative green sources are attracting more caution under sustainability targets, kapok and coconut fibers, known as natural fibers, have come to the fore as a very significant raw material source. In this experimental study, compressive strength, thermal insulation, and pore structure characteristics of kapok fiber (KP)– and coconut fiber (CC)–incorporated concrete samples under different curing conditions were analyzed. For that purpose, randomly distributed fiber-incorporated concrete mixtures containing 0%, 0.5%, 1%, and 1.5% KP and CC fiber by the weight of cement were prepared and under H2O2 and NaClO curing conditions, the effects of KP and CC fiber inclusion on properties mentioned above of fiber-incorporated concrete samples were researched in detail. Experimental results depict that a maximum thermal conductivity coefficient decrease of 24.31% was detected at a content ratio of 1.5% by the reason of the pore modification effect of used natural fibers in the H2O2 curing group. Because of the remarkable pore modification effect of KP fiber incorporation into the cement matrix compared to the CC fiber inclusion cases, strong linear correlations revealing the insulation-strength mechanism could be detected for both H2O2 and NaClO curing cases. This work intends to promote sustainable development in the building industry by integrating natural fibers into concrete mixtures as an innovative design approach. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
An analysis of the relationship of “the Mozart effect” with BDNF levels in anatomy education
(John Wiley and Sons Inc, 2024) Petekkaya, Emine; Ünalmış Aykar, Demet; Kaptan, Zülal
In 1993, an increase was observed in the spatial IQ scores of the volunteers who listened to Mozart's sonata K448 for 10 min, and this phenomenon entered the literature as the “Mozart effect.” Other studies have shown that this effect is particularly evident in spatial skill tests. A large body of research has provided evidence that spatial ability is associated with success in learning anatomy. In this study, Kastamonu University Faculty of Medicine students were divided into two groups during 16-h practical training spanning 30 days. While one of the groups listened to Mozart's K448 sonata as the background music in all lessons, the control group attended the lessons in their standard form. At the end of each lesson, all students solved a modified mental rotation test including questions involving anatomical structures. Before starting the study, after the first laboratory class, on the 15th and 30th day of the study, blood samples were taken from the participants, and plasma brain-derived neurotrophic factor (BDNF) levels were determined. The effect of time on mental rotation score and plasma BDNF level was significant (p < 0.001 for both). The effect of group was also significant (p < 0.001 for both). Pairwise comparisons showed significance in the fifth, sixth, seventh, and eighth mental rotation test (p < 0.001, p = 0.041, p < 0.001, p < 0.001, respectively) and in the third (Day 15) and fourth (Day 30) BDNF measurement (p < 0.001 for both). Our findings may indicate that specific background music may be useful for anatomy teaching. © 2024 American Association for Anatomy.
Nanostructured Surfaces with Plasmonic Activity and Superhydrophobicity: Review of Fabrication Strategies and Applications
(Wiley-V C H Verlag Gmbh, 2025) Ruzi, Mahmut; Celik, Nusret; Sahin, Furkan; Sakir, Menekse; Onses, M. Serdar
Plasmonics and superhydrophobicity have garnered broad interest from academics and industry alike, spanning fundamental scientific inquiry and practical technological applications. Plasmonic activity and superhydrophobicity rely heavily on nanostructured surfaces, providing opportunities for their mutually beneficial integration. Engineering surfaces at microscopic and nanoscopic length scales is necessary to achieve superhydrophobicity and plasmonic activity. However, the dissimilar surface energies of materials commonly used in fabricating plasmonic and superhydrophobic surfaces and different length scales pose various challenges to harnessing their properties in synergy. In this review, an overview of various techniques and materials that researchers have developed over the years to overcome this challenge is provided. The underlying mechanisms of both plasmonics and superhydrophobicity are first overviewed. Next, a general classification scheme is introduced for strategies to achieve plasmonic and superhydrophobic properties. Following that, applications of multifunctional plasmonic and superhydrophobic surfaces are presented. Lastly, a future perspective is presented, highlighting shortcomings, and opportunities for new directions.
Oral microbial dysbiosis in patients with oral cavity cancers
(Springer Heidelberg, 2024) Unlu, Ozge; Demirci, Mehmet; Paksoy, Tugce; Eden, Arzu Baygul; Tansuker, Hasan Deniz; Dalmizrak, Aysegul; Aktan, Cagdas
Objectives The pathogenesis of oral cavity cancers is complex. We tested the hypothesis that oral microbiota dysbiosis is associated with oral cavity cancer. Materials and methods Patients with primary oral cavity cancer who met the inclusion and exclusion criteria were included in the study. Matching healthy individuals were recruited as controls. Data on socio-demographic and behavioral factors, self-reported periodontal measures and habits, and current dental status were collected using a structured questionnaire and periodontal chartings. In addition to self-reported oral health measures, each participant received a standard and detailed clinical examination. DNA was extracted from saliva samples from patients and healthy controls. Next-generation sequencing was performed by targeting V3-V4 gene regions of the 16 S rRNA with subsequent bioinformatic analyses. Results Patients with oral cavity cancers had a lower quality of oral health than healthy controls. Proteobacteria, Aggregatibacter, Haemophilus, and Neisseria decreased, while Firmicutes, Bacteroidetes, Actinobacteria, Lactobacillus, Gemella, and Fusobacteria increased in oral cancer patients. At the species level, C. durum, L. umeaens, N. subflava, A. massiliensis, and V. dispar were significantly lower, while G. haemolysans was significantly increased (p < 0.05). Major periodontopathogens associated with periodontal disease (P. gingivalis and F.nucleatum) increased 6.5- and 2.8-fold, respectively. Conclusion These data suggested that patients with oral cancer had worse oral health conditions and a distinct oral microbiome composition that is affected by personal daily habits and may be associated with the pathogenicity of the disease and interspecies interactions. Clinical relevance This paper demonstrates the link between oral bacteria and oral cancers, identifying mechanistic interactions between species of oral microbiome.
Tooth numbering with polygonal segmentation on periapical radiographs: an artificial intelligence study
(Springer Heidelberg, 2024) Ayyildiz, Halil; Orhan, Mukadder; Bilgir, Elif; Celik, Ozer; Bayrakdar, Ibrahim Sevki
ObjectivesAccurately identification and tooth numbering on radiographs is essential for any clinicians. The aim of the present study was to validate the hypothesis that Yolov5, a type of artificial intelligence model, can be trained to detect and number teeth in periapical radiographs.Materials and methodsSix thousand four hundred forty six anonymized periapical radiographs without motion-related artifacts were randomly selected from the database. All periapical radiographs in which all boundaries of any tooth could be distinguished were included in the study. The radiographic images used were randomly divided into three groups: 80% training, 10% validation, and 10% testing. The confusion matrix was used to examine model success.ResultsDuring the test phase, 2578 labelings were performed on 644 periapical radiographs. The number of true positive was 2434 (94.4%), false positive was 115 (4.4%), and false negative was 29 (1.2%). The recall, precision, and F1 scores were 0.9882, 0.9548, and 0.9712, respectively. Moreover, the model yielded an area under curve (AUC) of 0.603 on the receiver operating characteristic curve (ROC).ConclusionsThis study showed us that YOLOv5 is nearly perfect for numbering teeth on periapical radiography. Although high success rates were achieved as a result of the study, it should not be forgotten that artificial intelligence currently only can be guides dentists for accurate and rapid diagnosis.Clinical RelevanceIt is thought that dentists can accelerate the radiographic examination time and inexperienced dentists can reduce the error rate by using YOLOv5. Additionally, YOLOv5 can also be used in the education of dentistry students.
Case-based report of graded motor imagery experience in traumatic brachial plexus injury: The art of moving without moving
(Hanley & Belfus-Elsevier Inc, 2024) Eren, Tuba; Kuru, Cigdem Ayhan; Harput, Gulcan; Leblebicioglu, Gursel
Background: We reported a 24 -year -old woman who sustained multiple upper limb injuries after a traffic accident in March 2017. She sustained a C7 -T1 brachial plexus injury and radial nerve injury on the left side diagnosed in November 2017. The patient underwent radial nerve reconstruction. The patient began her comprehensive therapy program in January 2018. Purpose: To describe the use of graded motor imagery (GMI) and outcomes after traumatic brachial plexus palsy. We presented changes in electromyographic (EMG) activity of target muscles during task execution and functional status following 10 -session GMI therapy. Study Design: Case report. Methods: The program included 4 sessions of motor imagery and 6 sessions of a combination of motor imagery and mirror therapy. Results: The patient successfully participated in the program with reported improvements in EMG activity, functional status, emotional well-being, and body awareness. Conclusions: GMI therapy appears to have peripheral motor effects, including altered surface EMG activity and contributes to a favorable outcome in the functional level of the affected arm. An improved emotional state and awareness of the affected hand could have a positive effect on function. Future long-term randomized controlled trials are needed to investigate the cumulative peripheral effects of treatment of graded motor imagery and the effects of variables mediating its effects on functional performance in patients with nerve injury. (c) 2024 Elsevier Inc. All rights reserved.
Is awareness of climate change a predictor of eco-anxiety? Research within the scope of nursing students
(Churchill Livingstone, 2024) Mat, Seda Tugba Baykara; Yilmaz, Buse Nur
Background: Understanding nursing students' awareness of climate change and its impact on their anxiety levels is crucial in representing a significant research area for the sustainability of healthcare services and the development of strategies to address climate change. Objectives: This study aims to determine nursing students' awareness of global climate change and eco-anxiety levels. Additionally, it seeks to uncover the relationship between these two factors. Design: During the academic year 2022-2023, this research was conducted with nursing students at a university in Istanbul, utilizing a cross-sectional and exploratory correlational design. The study involved 390 nursing students at the same university, aiming to reach the entire population without using any sampling method. Valid data were obtained from 374 students. The Student Information Form, University Students' Climate Change Awareness Scale and the Eco-anxiety Scale used as instruments for data collection. Subsequently, the data underwent analysis in a computational environment utilizing descriptive statistical methods and Pearson correlation analysis. Results: Most of the participants were female and single. The mean total global climate change awareness of the students was 75.072 +/- 15.094, and the mean general eco-anxiety of the students was 1.158 +/- 0.629. A weak positive relationship was found between the total global climate change awareness and general environmental concerns of the students participating in the study at r = 0.233 (p = 0.000 < 0.05). The level of awareness of climate change explains 5 % of nursing students' eco-anxiety levels. Conclusion: This study emphasizes a significant relationship between climate change awareness and increased ecological anxiety. Filling a gap in the field due to the lack of specific research focusing on nursing students highlights the importance of maintaining awareness to prevent ecological anxiety from reaching undesirable levels. This approach is crucial in actively encouraging nurses to contribute to developing educational curricula and environmentally friendly health policies.
Short and long-term blockades of adenosine 2A, 5-HT2A, and 5-HT7 receptors induce apoptosis, reduce proliferation, and show differential effects on miR-27b-3p expression in neuroblastoma cell lines
(Pergamon-Elsevier Science Ltd, 2024) Basaran, Kemal Erdem; Korkmaz, Seyda; Satir-Basaran, Guzide; Salkin, Hasan
The first of our aims in this study was to investigate the effects of 5-HT2AR, 5-HT7R, and A2AR blockades on miR-27b-3p expression in the short and long-term in neuroblastoma cells. Our second aim was to reduce the expression of pERK and suppress proliferation by blocking the 5-HT2AR with ketanserin. Our third aim was to reduce the expression of pAKT and induce apoptosis by blocking the A2AR and 5-HT7R with MSX3 and SB269970. Thus, we aimed to investigate the therapeutic efficacy of ketanserin, MSX3 and SB269970, individually or in combination, on neuroblastoma cells. We found that short and long-term blockades of A2A, 5-HT2A, and 5-HT7 receptors had different effects on miR-27b-3p expression. Blockade of A2AR and 5-HT7R with MSX3 and SB269970 decreased miR-27b-3p expression in the short term while increasing it in the long term. Ketanserin increased miR-27b-3p expression in both the short and long term. When 5-HT2AR was blocked with ketanserin, no significant difference was observed in pERK expression and proliferation in the short term. In contrast, a substantial decrease in pERK expression and proliferation was detected in the long term. Our findings show that the MSX3 + SB269970 dual combination and ketanserin + MSX3 + SB269970 triple combination are especially critical in suppressing pAKT expression in the long term. These findings showed that pAKT protein expression induced apoptosis due to decreased in neuroblastoma cells. Our study provides the first evidence for the relationships between ketanserin/miR-27b-3p/pERK, MSX3/miR27b-3p/pAKT, and SB269970/miR-27b-3p/pAKT in neuroblastoma cells. Ketanserin, MSX3, and SB269970 drug combinations may be promising therapeutic agents in neuroblastoma cells.
The Effect of Virtual Reality, Music Therapy, and Stress Ball Application on Pain and Anxiety During Outpatient Gynecological Procedures: A Randomized Controlled Trial
(Elsevier Science Inc, 2024) Oz, Tugba; Demirci, Nurdan
Purpose: The aim of this study was to determine the effect of virtual reality, music therapy, and stress ball applications, which are methods of distraction, on pain, anxiety, and patient satisfaction during outpatient gynecological procedures. Design: This study was a randomized controlled trial with control and intervention groups, pre-test and post-test. Methods: The study was conducted with 200 women who underwent gynecological surgical procedures without sedation in a state hospital on the European side of Istanbul between October 2022 and March 2023. There were four groups in the study: Virtual Reality (n = 50), Music Therapy (n = 50), Stress Ball (n = 50), and Control group (n = 50). Data were collected using a Descriptive Information Form, Visual Analog Scale, State-Trait Anxiety Inventory, Life Information Follow-up Form, and Patient Satisfaction Evaluation Form. The scales were completed separately by the investigator before the procedure, 10 minutes after the procedure, and 1 hour after the procedure. Findings: A statistically significant difference between the intervention groups and control groups of women who underwent a gynecological procedure at the 10th minute after the procedure (P=.000) and at the 1st hour after the procedure (P=.000) was significant. State-Trait Anxiety Inventory of women by groups decreased after the procedure and showed a statistically significant difference (P =.000). Satisfaction scores of the women with the intervention according to the groups also showed a significant difference (P =.000). When the satisfaction scores of the women with the intervention were compared by groups, the satisfaction scores ranged from the highest to the lowest, as virtual reality, music therapy, and stress ball application, respectively. Conclusions: Virtual reality, music therapy, and stress ball applications, which are methods of distraction during the outpatient gynecological procedure, were effective in reducing anxiety and pain and increasing patient satisfaction. (c) 2024 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Exploring Druggable Binding Sites on the Class A GPCRs Using the Residue Interaction Network and Site Identification by Ligand Competitive Saturation
(Amer Chemical Soc, 2024) Inan, Tugce; Yuce, Merve; MacKerell Jr, Alexander D.; Kurkcuoglu, Ozge
G protein-coupled receptors (GPCRs) play a central role in cellular signaling and are linked to many diseases. Accordingly, computational methods to explore potential allosteric sites for this class of proteins to facilitate the identification of potential modulators are needed. Importantly, the availability of rich structural data providing the locations of the orthosteric ligands and allosteric modulators targeting different GPCRs allows for the validation of approaches to identify new allosteric binding sites. Here, we validate the combination of two computational techniques, the residue interaction network (RIN) model and the site identification by ligand competitive saturation (SILCS) method, to predict putative allosteric binding sites of class A GPCRs. RIN analysis identifies hub residues that mediate allosteric signaling within a receptor and have a high capacity to alter receptor dynamics upon ligand binding. The known orthosteric (and allosteric) binding sites of 18 distinct class A GPCRs were successfully predicted by RIN through a dataset of 105 crystal structures (91 ligand-bound, 14 unbound) with up to 77.8% (76.9%) sensitivity, 92.5% (95.3%) specificity, 51.9% (50%) precision, and 86.2% (92.4%) accuracy based on the experimental and theoretical binding site data. Moreover, graph spectral analysis of the residue networks revealed that the proposed sites were located at the interfaces of highly interconnected residue clusters with a high ability to coordinate the functional dynamics. Then, we employed the SILCS-Hotspots method to assess the druggability of the novel sites predicted for 7 distinct class A GPCRs that are critical for a variety of diseases. While the known orthosteric and allosteric binding sites are successfully explored by our approach, numerous putative allosteric sites with the potential to bind drug-like molecules are proposed. The computational approach presented here promises to be a highly effective tool to predict putative allosteric sites of GPCRs to facilitate the design of effective modulators.
Comparing face-to-face and internet-based basic body awareness therapy for fibromyalgia: a randomized controlled trial
(Taylor & Francis Ltd, 2025) Tahran, O.; Huseyinsinoglu, B. Ersoz; Yolcu, G.; Saygi, E. Karadag; Yeldan, I.
Purpose: This study aimed to investigate and compare the effecs of face-to-face and internet-based Basic Body Awareness Therapy (BBAT), in patients with fibromyalgia (FM). Materials and methods: FM-diagnosed patients were randomly allocated to one of three groups: face-to-face BBAT (F2F-BBAT), internet-based BBAT (I-BBAT), or a waiting list control group (CG). The F2F-BBAT group underwent individual 8-week BBAT sessions (2 sessions per week). The I-BBAT group received an equivalent dosage of BBAT via online video conferencing software. The primary outcome was the Fibromyalgia Impact Questionnaire Revised (FIQR). Secondary outcomes included the pressure pain threshold (PPT) via algometer, the PostureScreen Mobile (R) (PSM) application, the Short Form McGill Pain Questionnaire (SF-MPQ), the Short Form 36 Health Survey (SF-36), and plasma fibrinogen and haptoglobin levels. Results: A total of 41 patients completed the study. Both the F2F-BBAT (n = 14) and I-BBAT (n = 13) groups showed significant improvements in all outcome measures (p < 0.05) with no significant difference between them (p > 0.05). Conversely, the CG (n = 14) demonstrated no substantial improvements in the outcome measures (p > 0.05). Compared to the CG, both the F2F-BBAT and I-BBAT groups exhibited superior results in FIQR, PPT, PSM, SF-MPQ, and multiple SF-36 sub-parameters (p < 0.05). Conclusion: This study showed that BBAT delivered via internet-based telerehabilitation can have comparable effective results on clinical parameters with conventional face-to face BBAT in patients with FM. Trial registration: ClinicalTrials.gov: NCT04981132.
Detection, characterization and antimicrobial susceptibility of Clostridioides difficile from seafood of Marmara Sea, Turkey
(Taylor & Francis Ltd, 2024) Akkaya, Esra; Hampikyan, Hamparsun; Muratoglu, Karlo; Colak, Hilal; Bingol, Enver Baris
The objective of this study was to determine the presence of C. difficile in seafood, to identify the ribotype of isolates, to reveal the distribution of their toxinogenic genes and to evaluate the antibiotic susceptibility of C. difficile strains. For this purpose, a total of 755 seafood samples were analysed. Sixteen isolates were verified as C. difficile [14 (5.28%) bivalve molluscs and 2 (2.0%) shrimp] whereas none of the ribotypes detected were human pathogenic ribotypes. Among C. difficile isolates only one of the bivalve mollusc (RT003) was found to be toxigenic (A+B+CDT+) that had also toxin-producing ability. All isolates were sensitive to vancomycin and resistant to cefotaxime. Results of this study indicate that the rate of C. difficile in seafood is much lower than in meat or poultry products. However, consumption of raw or undercooked contaminated bivalve molluscs could be a potential source of C. difficile that may pose a risk to human health.
Social Workers' Working Experiences with Men in the Provision of Mental Health Services
(Routledge Journals, Taylor & Francis Ltd, 2025) Akcay, Sinan; Akar, Bilge
The aim of this study is to understand the experiences of social workers, who have important roles and responsibilities in the provision of mental health services, in working with men with mental health problems. In the study which adopted qualitative descriptive design, in-depth interviews were conducted with 18 social workers. As a result of the analysis of the interviews using the thematic analysis method, three themes were obtained: the reflections of masculinity norms in mental health services, difficulties encountered while working with men and opportunities offered by the social work profession. Research findings indicated that masculinity norms were important determinants at every stage of mental disorders, from the awareness of symptoms to the prosecution of the treatment. Although social workers encountered various difficulties when working with men, the principles and values of social work offered an important opportunity during their work. The study also indicated that mental health policies and services should be gender-sensitive in order to carry out effective practices in the field of male mental health.
Ponatinib and STAT5 Inhibitor Pimozide Combined Synergistic Treatment Applications Potentially Overcome Drug Resistance via Regulating the Cytokine Expressional Network in Chronic Myeloid Leukemia Cells
(Mary Ann Liebert, Inc, 2024) Tezcanli Kaymaz, Burcin; Gumus, Nurcan; Celik, Besne; Alcitepe, Ilayda; Biray Avci, Cigir; Aktan, Cagdas
Chronic myeloid leukemia (CML) is a clonal myeloproliferative hematological disease characterized by the chimeric breakpoint-cluster region/Abelson kinase1 (BCR
Neutrophil-platelet ratio as a predictor of acute kidney injury in severe COVID-19
(Lippincott Williams & Wilkins, 2024) Sayan, Mihrican; Altinisik, Hatice Betul; Sayan, Ozan
Acute kidney injury (AKI) is one of the most seen complications of coronavirus-2019 (COVID-19) infection. Patients with AKI caused by COVID-19 likely have higher neutrophil counts and lower platelet and lymphocyte levels. Therefore, the predictive value of many inflammation indexes calculated from the total blood count has been investigated to predict the AKI in COVID-19. According to our clinical experience, we thought that neutrophilia and thrombocytopenia may be more common in the development of AKI. For this reason, this study aimed to evaluate the predictive value of the neutrophil-to-platelet ratio (NPR) for AKI in severe COVID-19 patients. This retrospective study included 334 severe COVID-19 patients followed up in the intensive care unit (ICU). Predictive factors for AKI were analyzed. ROC curve analysis was performed to determine the inflammation indexes' cutoff values for the AKI prediction. Multivariate analyses were performed to determine correlations between the inflammation indexes and AKI. In this study, AKI was determined at the rate of 43% (n:145). Independent risk factors affecting AKI were determined to be age (HR = 1.047, 95% confidence interval [CI]: 1.021-1.072, P < .001), the need for invasive mechanical ventilation (HR = 3.003, 95% CI: 1.645-5.481, P = .001) and the need for vasopressor (HR = 8.111, 95% CI: 3.786-17.375, P < .001). The optimal cutoff values predicting AKI were determined to be 3.9 for the NPR (AUC = 0.679, 95% CI: 0.622-0.737, P < .001) with 71.7% sensitivity and 61.9% specificity, 16.1 for the neutrophil-to-lymphocyte ratio (NLR) (AUC = 0.634, 95% CI: 0.575-0.694, P < .001) with 65.5% sensitivity and 56.1% specificity, and 3872.5 x 10(9)L for the systemic inflammatory index (SII) (AUC = 0.566, 95% CI: 0.504-0.629, P = .038) with 60% sensitivity and 55.6% specificity. In the regression model, only NPR values above the cutoff were related to AKI (HR = 3.817, 95% CI: 1.782-8.177, P = .001). The NPR has more predictive value than the NLPR, NLR, and SII in developing AKI in severe COVID-19 patients in the ICU. NPR is a new helpful index that can help clinicians predict early AKI in critical COVID-19.
Effect of evidence-based nursing practices on individualised care: A cross-sectional descriptive study
(Wiley, 2025) Ozdemir, Cevriye; Sendir, Merdiye; Eren, Rabia; Bakir, Gizem Kubat; Kizil, Hamiyet
Aim: This study was conducted to determine the effect of nurses' attitudes towards evidence-based practices on individualised nursing care. Methods: This study is a cross-sectional descriptive trial. The descriptive analysis included 200 clinical nurses working in a private hospital between April and September 2022. Data were collected with a personal information form, Individualised Care Scale (A-Nurse Version), and Evidence-Based Nursing Attitude Questionnaire. The relationship between the scales and effect was examined by Pearson correlation and linear regression analyses. T-test, one-way analysis of variance (ANOVA), and post hoc (Tukey, LSD) analysis were used in the statistical analysis of nurses according to their descriptive characteristics. This study has adhered to the STROBE checklist for reporting. Results: They had high mean scores on Individualised Care Scale total (3.68 +/- 1.25) and from Clinical Situation (3.78 +/- 1.30) and Decisional Control (3.82 +/- 1.35) subscales and average score from the Personal Life (3.32 +/- 1.29) subscale. Their mean score from the Evidence-Based Nursing Attitude Questionnaire was average (47.64 +/- 10.99). There was a positive moderate (r = 0.50, p = 0.000 < 0.05) significant correlation between the scales. Conclusion: Positive attitude towards evidence-based nursing practices positively affects individualised care. Variables such as professional experience positively affect nurses' attitudes towards evidence-based nursing. A positive and significant relationship was found between nurses' attitudes towards evidence-based practice and their attitudes towards individualised care.

Güncel Gönderiler