İstanbul Beykent Üniversitesi Kurumsal Akademik Arşivi
DSpace@Beykent, İstanbul Beykent Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
NONLINEAR LOVE WAVES IN A HOMOGENEOUS LAYER OVERLYING A HOMOGENEOUS HALF-SPACE
(Turkic World Mathematical Soc, 2025) Demirkus, D.
In this article, the focus is on the propagation of Love waves in a solid layer overlying a solid half-space, assuming that both layer and half-space consist of nonlinear, isotropic, homogeneous, hyper-elastic, and generalized neo-Hookean materials, in addition to having different mechanical properties. As done by Love, displacements and stresses are assumed to be continuous at the interface between the layer and half-space, and the upper surface is to be free from traction, in addition to holding the radiation condition in the half-space. The method of multiple scales in the self modulation of the problem is used. Then, it is shown that the self modulation of the problem can be given by a nonlinear Schrodinger equation as a result of a balance between dispersion and nonlinearity. By using the coefficients of the nonlinear Schrodinger equation, the existence of the solitary waves is studied. In addition, the effects of the parameters of linear and nonlinear mediums on the functions of the wave propagation are studied.
Neutrophil precursors in complete blood count: innovative biomarker for acute pulmonary embolism severity
(Lithographia, 2025) Karakurt, G.; Ozatak, C.; Guven, O.; Naser, A.; Aynaci, E.
Background: Inflammation plays an important role in the pathogenesis of acute pulmonary embolism (APE), which is a cardiovascular emergency associated with high mortality. The primary determinant of the clinical course in the setting of APE is right ventricular dysfunction (RVD). In this study, we aim to investigate the usefulness of circulating immature granulocytes (IG) as an inflammatory biomarker in predicting RVD in APE. Methods: We retrospectively analyzed data of 59 patients admitted to the emergency department between January 2019 and June 2022, diagnosed with APE. A complete blood count at admission determined the IG count. According to their echocardiographic evaluation, patients were divided into two groups according to the presence of RVD. Results: We observed in APE that the mean IG count was significantly higher in patients with RVD than those without RVD (p =0.001). The multivariate logistic regression analysis detected a significant (p =0.006) and independent effect of the IG count in distinguishing cases with and without RVD. Conclusions: We found the discriminative effectiveness of the IG 0.05 cut-off value for RVD. IGs, an inflammatory precursor obtained readily and without additional cost as part of a complete blood count, may be a new and valuable biomarker for risk stratification and prognosis assessment by predicting RVD in APE patients. HIPPOKRATIA 2025, 29 (1):20-24.
Comparison of Ultrasound-Guided Perineural 5% Dextrose Prolotherapy and Corticosteroid Injection in Mild to Moderate Carpal Tunnel Syndrome: A Retrospective Clinical Study
(Pera Yayincilik Hizmetleri, 2025) Guloglu, Sevtap Badil; Sahbaz, Tugba; Filiz, Meral Bilgilisoy; Dogan, Sebnem Koldas; Asik, Hatice Kubra
Objective: Carpal tunnel syndrome (CTS) is a common entrapment neuropathy caused by median nerve compression. Steroid injections provide temporary relief in mild to moderate CTS, whereas 5% dextrose prolotherapy (PrT) has recently emerged as a regenerative alternative. This study compares the efficacy of ultrasound-guided perineural 5% dextrose PrT and corticosteroid injections. Methods: In this retrospective analysis, 74 individuals aged between 18 and 70 years, meeting both clinical and electrophysiological criteria for mild to moderate CTS, were included. 36 patients received a single ultrasound-guided injection of 40 mg triamcinolone acetonide (steroid group), while 38 patients underwent three perineural 5% dextrose PrT sessions at three-week intervals (PrT group). All patients followed a 12-week conservative protocol with wrist splinting and nerve/tendon gliding exercises. Outcomes were assessed at baseline, week 6, and week 24. The primary outcome was Visual Analog Scale (VAS) pain and numbness score. Secondary outcomes were QuickDASH, grip and pinch strengths, and median nerve conduction studies. Results: Both groups showed significant within-group clinical and functional improvements (p<0.05). At 6 weeks, the steroid group showed higher grip strength compared with PrT (MD = -1.25, 95% CI -4.12 to 1.62, p = 0.048) and pinch (MD = -0.32, 95% CI -0.87 to 0.23, p = 0.005) compared with the prolotherapy group. At 24 weeks, PrT resulted in lower daytime pain VAS compared with steroids (MD -1.15, 95% CI -2.23 to -0.07, p = 0.026), surpassing the minimal clinically important difference (MCID) for CTS pain reduction. Electrophysiological improvements occurred only in the steroid group, especially in motor and sensory conduction parameters, without corresponding long-term clinical superiority. Conclusion: Perineural PrT and steroid injections appear to be effective non-surgical options for managing mild to moderate CTS. While steroids may provide faster symptom relief and earlier improvements in strength, dextrose PrT demonstrated more sustained pain reduction. It should be noted, however, that the injection protocols differed-the steroid group received a single dose, whereas the PrT group underwent three sessions-an approach based on our review of the existing literature. This discrepancy should be considered when interpreting the results. Further randomized controlled trials are needed to confirm these findings and clarify the regenerative mechanisms of dextrose prolotherapy.
Concurrent validation of an immersive virtual reality version of the box and block test, the 360° turn test, and the five times sit-to-stand test to assess the functional status of stroke patients
(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2025) Menekseoglu, Ahmet Kivanc; Sezikli, Selim; Bilget, Selen; Yilmaz, Umut; Sahbaz, Tugba
Objectives: This study aims to develop immersive virtual reality (VR) versions of the box and block test (BBT), the 360 degrees turn test, and five times sit-to-stand (5TSTS) test to evaluate functional status within a VR-mediated gamified environment and assess their concurrent validity. Patients and methods: Thirty participants (18 males, 12 females; mean age: 59.9 +/- 11.9 years; range, 25 to 82 years) with a stroke diagnosis were included in the prospective study between February 2024 and August 2024. Each participant completed the BBT, 360 degrees turn test, and 5TSTS test three times using both VR-based and traditional methods. Concurrent validity was examined by analyzing the correlations between VR-mediated and traditional test results. The test-retest reliability of the VR-based assessments was evaluated using intraclass correlation coefficients (ICCs). The usability of the developed software was also assessed using the System Usability Scale Results: Strong correlations were found between VR-based and traditional assessment methods for the affected side in the BBT (r=0.562; p<0.001), in the 360 degrees turn test (r=0.838; p<0.001), and 5TSTS (r=0.733; p<0.001). Interrater reliability was high and statistically significant across all tests (ICC >0.80, p<0.001). The usability of the developed software was rated as good (mean System Usability Scale score: 70.8 +/- 15.6). Conclusion: The VR-based versions of the BBT, 360 degrees turn test, and 5TSTS are valid, reliable, and user-friendly tools for assessing functional status in stroke patients. These assessments show promise for integration into clinical settings and remote rehabilitation programs.
Impact of Plant and Microbial Proteases Treatment on Quality Characteristics of Beef Longissimus Thoracis and Lumborum
(Korean Soc Food Science Animal Resources, 2025) Akkaya, Esra; Bingol, Enver Baris; Hampikyan, Hamparsun; Colak, Hilal
This study was aimed to determine the effects of accelerated aging process provided by enzyme treatments (0.01 g/kg, 0.02 g/kg and 0.05 g/kg concentrations of papain, bromelain and fungal protease enzymes) on the quality characteristics of longissimus thoracis (LT) and longissimus lumborum (LL) muscles. For this purpose, LT and LL muscles, obtained from a commercial plant at 24 h post-mortem, were subjected to enzyme treatments. Treated samples were vacuum packed and kept at 2 +/- 1 degrees C for physico-chemical, microbiological, instrumental and sensorial analyses on days 1, 2, and 5 of the aging process. Papain, bromelain and fungal protease treatments decreased the water activity, moisture and water holding capacity compared to untreated samples, while the bacterial load of enzyme-treated LT and LL samples was lower than that of untreated ones. Moreover, a significant difference was observed in shear force values between enzyme-treated and untreated samples during aging period (p<0.001) with a remarkable decrease by increasing concentration of enzyme that resulted in accelerated aging process. Papain treatment provided the greatest tenderness, while low concentrations (0.01 and 0.02 g/kg) of bromelain enhanced the palatability of the product. Considering muscle type, LT samples were more appreciated in terms of textural and sensorial properties compared to the LL samples. The results revealed that treatment with plant and microbial proteases improved the quality parameters of beef meat depending on the enzyme concentration to providing palatable meat in a reduced aging period.
