Methodology For Analysis And Reporting Patterns Of Failure İn The Era Of IMRT: Head And Neck Cancer Applications

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dc.authorid233754en_US
dc.contributor.authorKoçak Uzel, Esengül
dc.contributor.author., ve diğer
dc.date.accessioned2019-07-16T13:11:49Z
dc.date.available2019-07-16T13:11:49Z
dc.date.issued2016
dc.departmentİstanbul Beykent Üniversitesien_US
dc.description.abstractBackground: The aim of this study is to develop a methodology to standardize the analysis and reporting of the patterns of loco-regional failure after IMRT of head and neck cancer. Material and Methods: Twenty-one patients with evidence of local and/or regional failure following IMRT for head-and-neck cancer were retrospectively reviewed under approved IRB protocol. Manually delineated recurrent gross disease (rGTV) on the diagnostic CT documenting recurrence (rCT) was co-registered with the original planning CT (pCT) using both deformable (DIR) and rigid (RIR) image registration software. Subsequently, mapped rGTVs were compared relative to original planning target volumes (TVs) and dose using a centroid-based approaches. Failures were then classified into five types based on combined spatial and dosimetric criteria; A (central high dose), B (peripheral high dose), C (central elective dose), D (peripheral elective dose), and E (extraneous dose). Results: A total of 26 recurrences were identified. Using DIR, recurrences were assigned to more central TVs compared to RIR as detected using the spatial centroid-based method (p = 0.0002). rGTVs mapped using DIR had statistically significant higher mean doses when compared to rGTVs mapped rigidly (mean dose 70 vs. 69 Gy, p = 0. 03). According to the proposed classification 22 out of 26 failures were of type A (central high dose) as assessed by DIR method compared to 18 out of 26 for the RIR because of the tendencey of RIR to assign failures more peripherally. Conclusions: RIR tends to assigns failures more peripherally. DIR-based methods showed that the vast majority of failures originated in the high dose target volumes and received full prescribed doses suggesting biological rather than technology-related causes of failure. Validated DIR-based registration is recommended for accurate failure characterization and a novel typology-indicative taxonomy is recommended for failure reporting in the IMRT era.en_US
dc.identifier.doi10.1186/s13014-016-0678-7
dc.identifier.issn1748-717X
dc.identifier.pmid27460585en_US
dc.identifier.scopus2-s2.0-85016089228en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/s13014-016-0678-7
dc.identifier.wosWOS:000380232900003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBMCtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.subjectPatterns of failuretr_TR
dc.subjectIMRTtr_TR
dc.subjectHead-and-neck cancertr_TR
dc.subjectDeformable image registrationtr_TR
dc.titleMethodology For Analysis And Reporting Patterns Of Failure İn The Era Of IMRT: Head And Neck Cancer Applicationsen_US
dc.typeArticleen_US

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