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Association Between Human Leukocyte Antigen Gene Polymorphisms And Multiple Epıya-C Repeats İn Gastrointestinal Disorders
(Baishideng Publishing Group Inc, 2020) Demirci, Mehmet; Demiryas, Süleyman; Yılmaz, Erkan; Uysal, Ömer; Kepil, Nuray; ., ve diğer.
Background: Polymorphisms of human leukocyte antigen (HLA) genes are suggested to increase the risk of gastric cancer (GC). Aim: To investigate the HLA allele frequencies of patients with GC relative to a control group in terms of CagA+ multiple (? 2) EPIYA-C repeats. Methods: The patient group comprised 94 patients [44 GC and 50 duodenal ulcer (DU) patients], and the control group comprised 86 individuals [(50 non-ulcer dyspepsia patients and 36 people with asymptomatic Helicobacter pylori (H. pylori)]. Polymerase chain reaction was performed for the amplification of the H. pylori cagA gene and typing of EPIYA motifs. HLA sequence-specific oligonucleotide (SSO) typing was performed using Lifecodes SSO typing kits (HLA-A, HLA-B HLA-C, HLA-DRB1, and HLA-DQA1-B1 kits). Results: The comparison of GC cases in terms of CagA+ multiple (? 2) EPIYA-C repeats showed that only the HLA-DQB1*06 allele [odds ratio (OR): 0.37, P = 0.036] was significantly lower, but significance was lost after correction (Pc = 0.1845). The HLA-DQA1*01 allele had a high ratio in GC cases with multiple EPIYA-C repeats, but this was not significant in the univariate analysis. We compared allele frequencies in the DU cases alone and in GC and DU cases together using the same criterion, and none of the HLA alleles were significantly associated with GC or DU. Also, none of the alleles were detected as independent risk factors after the multivariate analysis. On the other hand, in a multivariate logistic regression with no discriminative criterion, HLA-DQA1*01 (OR = 1.848), HLA-DQB1*06 (OR = 1.821) and HLA-A*02 (OR = 1.579) alleles were detected as independent risk factors for GC and DU. Conclusion: None of the HLA alleles were detected as independent risk factors in terms of CagA+ multiple EPIYA-C repeats. However, HLA-DQA1*01, HLA-DQB1*0601, and HLA-A*2 were independent risk factors with no criterion in the multivariate analysis. We suggest that the association of these alleles with gastric malignancies is not specifically related to cagA and multiple EPIYA C repeats.
Azimuthal Separation in Nearly Back-To-Back Jet Topologies in İnclusive 2- And 3-Jet Events İn pp Collisions At ?s = 13TeV
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
A measurement for inclusive 2- and 3-jet events of the azimuthal correlation between the two jets with the largest transverse momenta, ??12, is presented. The measurement considers events where the two leading jets are nearly collinear (“back-to-back”) in the transverse plane and is performed for several ranges of the leading jet transverse momentum. Proton-proton collision data collected with the CMS experiment at a center-of-mass energy of 13TeV and corresponding to an integrated luminosity of 35.9fb?1 are used. Predictions based on calculations using matrix elements at leading-order and next-to-leading-order accuracy in perturbative quantum chromodynamics supplemented with leading-log parton showers and hadronization are generally in agreement with the measurements. Discrepancies between the measurement and theoretical predictions are as large as 15%, mainly in the region 177?
Beyond nPDFs Effects : Prompt J/? And ?(2s) Production İn pPb And Pp Collisions
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
A multi-dimensional analysis of prompt charmonia in pp and pPb collisions at ? sNN = 5.02 TeV with the CMS detector is resented. The pPb differential cross-sections of prompt J/? are shown in a wide kinematic region, for transverse momentum pT spanning from 2 to 30 GeV/c and a rapidity interval between -2.4 to 1.93 in the center of mass of the collision. The final results on prompt ?(2S) meson production cross section in pp and pPb collisions at 5.02 TeV are also reported as a function of pT and rapidity, for pT from 4 to 30 GeV/c. The nuclear modification factor is found to be smaller than that of prompt J/? in all measured bins, especially at low pT and at backward rapidity. Such a different behaviour between the ground and excited states cannot be reproduced considering nPDF effects alone.
Bose-Einstein Correlations Of Charged Hadrons İn Proton-Proton Collisions At s=13 TeV
(CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
Bose-Einstein correlations of charged hadrons are measured over a broad multiplicity range, from a few particles up to about 250 reconstructed charged hadrons in proton-proton collisions at s = 13 TeV. The results are based on data collected using the CMS detector at the LHC during runs with a special low-pileup configuration. Three analysis techniques with different degrees of dependence on simulations are used to remove the non-Bose-Einstein background from the correlation functions. All three methods give consistent results. The measured lengths of homogeneity are studied as functions of particle multiplicity as well as average pair transverse momentum and mass. The results are compared with data from both CMS and ATLAS at s = 7 TeV, as well as with theoretical predictions.
Calibration Of The Cms Hadron Calorimeters Using Proton-Proton Collision Data At Root s=13 TeV
(The CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar < 3 and are positioned inside the solenoidal magnet. An outer calorimeter, outside the magnet coil, covers vertical bar eta vertical bar < 1.26, and a steel and quartz-fiber Cherenkov forward calorimeter extends the coverage to vertical bar eta vertical bar < 5.19. The initial calibration of the calorimeters was based on results from test beams, augmented with the use of radioactive sources and lasers. The calibration was improved substantially using proton-proton collision data collected at root s = 7, 8, and 13 TeV, as well as cosmic ray muon data collected during the periods when the LHC beams were not present. The present calibration is performed using the 13 TeV data collected during 2016 corresponding to an integrated luminosity of 35.9 fb(-1). The intercalibration of channels exploits the approximate uniformity of energy collection over the azimuthal angle. The absolute energy scale of the central and endcap calorimeters is set using isolated charged hadrons. The energy scale for the electromagnetic portion of the forward calorimeters is set using Z -> ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.
Centrality And Pseudorapidity Dependence Of The Transverse Energy Density İn pPb Collisions At ?Snn = 5.02 Tev
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
The almost hermetic coverage of the CMS detector is used to measure the distribution of transverse energy, ET, over 13.2 units of pseudorapidity, ?, for pPb collisions at a center-of-mass energy per nucleon pair of ?s NN = 5.02 TeV. The huge angular acceptance exploits the fact that the CASTOR calorimeter at ?6.6 < ? < ?5.2 is effectively present on both sides of the colliding system because of a switch in the protongoing and lead-going beam directions. This wide acceptance enables the study of correlations between well-separated angular regions and makes the measurement a particularly powerful test of event generators. For minimum bias pPb collisions the maximum value of dET/d? is 22 GeV, which implies an ET per participant nucleon pair comparable to that of peripheral PbPb collisions at ? s NN = 2.76 TeV. The increase of dET/d? with centrality is much stronger for the lead-going side than for the proton-going side. The ? dependence of dET/d? is sensitive to the ? range in which the centrality variable is defined. Several modern generators are compared to these results but none is able to capture all aspects of the ? and centrality dependence of the data and the correlations observed between different ? regions.
Charged-Particle Angular Correlations İn Xexe Collisions At ?Snn = 5.44 TeV
(The CMS Collaboration, 2019) Bilki, Burak; Gürpınar Güler, Emine; ., ve diğer.
Azimuthal correlations of charged particles in xenon-xenon collisions at a center-of-mass energy per nucleon pair of ? sNN = 5.44 TeV are studied. The data were collected by the CMS experiment at the LHC with a total integrated luminosity of 3.42 ?b?1. The collective motion of the system formed in the collision is parametrized by a Fourier expansion of the azimuthal particle density distribution. The azimuthal anisotropy coefficients v2, v3, and v4 are obtained by the scalar-product, two-particle correlation, and multiparticle correlation methods.Within a hydrodynamic picture, these methods have different sensitivities to noncollective and fluctuation effects. The dependence of the Fourier coefficients on the size of the colliding system is explored by comparing the xenonxenon results with equivalent lead-lead data. Model calculations that include initial-state fluctuation effects are also compared to the experimental results. The observed angular correlations provide new constraints on the hydrodynamic description of heavy ion collisions.
Combination Of Cms Searches For Heavy Resonances Decaying To Pairs Of Bosons Or Leptons
(The CMS Collaboration, 2019) Gürpınar Güler, Emine; Bilki, Burak; ., ve diğer.
A statistical combination of searches for heavy resonances decaying to pairs of bosons or leptons is presented. The data correspond to an integrated luminosity of 35.9 fb?1 collected during 2016 by the CMS experiment at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV. The data are found to be consistent with expectations from the standard model background. Exclusion limits are set in the context of models of spin-1 heavy vector triplets and of spin-2 bulk gravitons. For massdegenerate W0 and Z0 resonances that predominantly couple to the standard model gauge bosons, the mass exclusion at 95% confidence level of heavy vector bosons is extended to 4.5 TeV as compared to 3.8 TeV determined from the best individual channel. This excluded mass increases to 5.0 TeV if the resonances couple predominantly to fermions.
Combination of Searches for Higgs Boson Pair Production in Proton-Proton Collisions at ? s = 13 TeV
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
This Letter describes a search for Higgs boson pair production using the combined results from four final states: bb??, bb??, bbbb, and bbVV, where V represents a W or Z boson. The search is performed using data collected in 2016 by the CMS experiment from LHC proton-proton collisions at ffiffiffi ps ¼ 13 TeV, corresponding to an integrated luminosity of 35.9 fb?1. Limits are set on the Higgs boson pair production cross section. A 95% confidence level observed (expected) upper limit on the nonresonant production cross section is set at 22.2 (12.8) times the standard model value. A search for narrow resonances decaying to Higgs boson pairs is also performed in the mass range 250–3000 GeV. No evidence for a signal is observed, and upper limits are set on the resonance production cross section.
Combination Of The W Boson Polarization Measurements İn Top Quark Decays Using Atlas And Cms Data At Root S=8 Tev
(CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
The combination of measurements of the W boson polarization in top quark decays performed by the ATLAS and CMS ollaborations is presented. The measurements are based on proton-proton collision data produced at the LHC at a centre-of-mass energy of 8 TeV, and corresponding to an integrated luminosity of about 20 fb?1 for each experiment. The measurements used events containing one lepton and having different jet multiplicities in the final state. The results are quoted as fractions of W bosons with longitudinal (F0 ), left-handed (FL), or right-handed (FR) polarizations. The resulting combined measurements of the polarization fractions are F0 = 0.693 ± 0.014 and FL = 0.315 ± 0.011. The fraction FR is calculated from the unitarity constraint to be FR = ?0.008 ± 0.007. These results are in agreement with the standard model predictions at next-to-next-to-leading order in perturbative quantum chromodynamics and represent an improvement in precision of 25 (29)% for F0 (FL) with respect to the most precise single measurement. A limit on anomalous right-handed vector (VR), and left- and right-handed tensor (gL, gR) tWb couplings is set while fixing all others to their standard model values. The allowed regions are [?0.11, 0.16] for VR, [?0.08, 0.05] for gL, and [?0.04, 0.02] for gR, at 95% confidence level. Limits on the corresponding Wilson coefficients are also derived.
Combinations Of Single-Top-Quark Production Cross-Section Measurements And |Flv Vtb| Determinations At ?s = 7 And 8 Tev With The Atlas And Cms Experiments
(The CMS Collaboration, 2019) Bilki, Burak; Gürpınar Güler, Emine; ., ve diğer.
This paper presents the combinations of single-top-quark production cross-section measurements by the ATLAS and CMS Collaborations, using data from LHC proton-proton collisions at s? = 7 and 8 TeV corresponding to integrated luminosities of 1.17 to 5.1 fb?1 at s? = 7 TeV and 12.2 to 20.3 fb?1 at s? = 8 TeV. These combinations are performed per centre-of-mass energy and for each production mode: t-channel, tW, and s-channel. The combined t-channel cross-sections are 67.5 ± 5.7 pb and 87.7 ± 5.8 pb at s? = 7 and 8 TeV respectively. The combined tW cross-sections are 16.3 ± 4.1 pb and 23.1 ± 3.6 pb at s? = 7 and 8 TeV respectively. For the s-channel cross-section, the combination yields 4.9 ± 1.4 pb at s? = 8 TeV. The square of the magnitude of the CKM matrix element Vtb multiplied by a form factor fLV is determined for each production mode and centre-of-mass energy, using the ratio of the measured cross-section to its theoretical prediction. It is assumed that the top-quark-related CKM matrix elements obey the relation |Vtd|, |Vts| ? |Vtb|. All the |fLVVtb|2 determinations, extracted from individual ratios at s? = 7 and 8 TeV, are combined, resulting in |fLVVtb| = 1.02 ± 0.04 (meas.) ± 0.02 (theo.). All combined measurements are consistent with their corresponding Standard Model predictions.
Combined Measurements of Higgs Boson Couplings in Proton–Proton Collisions at ? s = 13TeV
(CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
Combined measurements of the production and decay rates of the Higgs boson, as well as its couplings to vector bosons and fermions, are presented. The analysis uses the LHC proton–proton collision data set recorded with the CMS detector in 2016 at ?s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb?1. The combination is based on analyses targeting the five main Higgs boson production mechanisms (gluon fusion, vector boson fusion, and associated production with a W or Z boson, or a top quarkantiquark pair) and the following decay modes: H ? ??, ZZ, WW, ??, bb, and ??. Searches for invisible Higgs boson decays are also considered. The best-fit ratio of the signal yield to the standard model expectation is measured to be ? = 1.17 ± 0.10, assuming a Higgs boson mass of 125.09 GeV. Additional results are given for various assumptions on the scaling behavior of the production and decay modes, including generic parametrizations based on ratios of cross sections and branching fractions or couplings. The results are compatible with the standardmodel predictions in all parametrizations considered. In addition, constraints are placed on various two Higgs doublet models.
Combined Search For Supersymmetry With Photons İn Proton-Proton Collisions At Root s=13 TeV
(CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
A combination of four searches for new physics involving signatures with at least one photon and large missing transverse momentum, motivated by generalized models of gauge-mediated supersymmetry (SUSY) breaking, is presented. All searches make use of proton-proton collision data at root s = 13 TeV, which were recorded with the CMS detector at the LHC in 2016, and correspond to an integrated luminosity of 35.9 fb(-1). Signatures with at least one photon and large missing transverse momentum are categorized into events with two isolated photons, events with a lepton and a photon, events with additional jets, and events with at least one high-energy photon. No excess of events is observed beyond expectations from standard model processes, and limits are set in the context of gauge-mediated SUSY. Compared to the individual searches, the combination extends the sensitivity to gauge-mediated SUSY in both electroweak and strong production scenarios by up to 100GeV in neutralino and chargino masses, and yields the first CMS result combining various SUSY searches in events with photons at root s = 13 TeV.
Comprehensive Analysis Of The Transient X-Ray Pulsar Maxı J1409 619
(Oxford University Press, 2020) Şahiner, Şeyda; İnam, Sıtkı Çağdaş; ., ve diğer.
We probe the properties of the transient X-ray pulsar MAXI J1409-619 through RXTE and Swift follow-up observations of the outburst in 2010. We are able to phase-connect the pulse arrival times for the 25 d episode during the outburst. We suggest that either an orbital model (with P-orb similar or equal to 14.7(4) d) or a noise process due to random torque fluctuations (with S-r approximate to 1.3 x 10(-18) Hz(2) S-2 Hz(-1)) is plausible to describe the residuals of the timing solution. The frequency derivatives indicate a positive torque-luminosity correlation, which implies temporary accretion disc formation during the outburst. We also discover several quasiperiodic oscillations in company with their harmonics whose centroid frequencies decrease as the source flux decays. The variation of the pulsed fraction and spectral power-law index of the source with X-ray flux is interpreted as the sign of transition from a critical to a subcritical accretion regime at the critical luminosity within the range of 6 x 10(37)-1.2 x 10(38) erg s(-1). Using pulse-phase-resolved spectroscopy, we show that the phases with higher flux tend to have lower photon indices, indicating that the polar regions produce spectrally harder emission.
Constraints on the chi(c1 )versus chi(c2) Polarizations in Proton-Proton Collisions at root s=8 TeV
(The CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
The polarizations of promptly produced chi(c1) and chi(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at root s = 8 TeV. The chi(c) states are reconstructed via their radiative decays chi(c) -> J/psi gamma, with the photons being measured through conversions to e(+)e(-), which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the chi(c2) to chi(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/psi -> mu(+)mu(-) decay, in three bins of J/psi transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the hclicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum.
D0-Meson RAA in PbPb Collisions at ? sNN = 5.02 TeV and Elliptic Flow in pPb Collisions at ? sNN = 8.16 TeV with CMS
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
The study of charm production in heavy-ion collisions is considered an excellent probe for the properties of the hot and dense medium created in heavy-ion collisions. Measurements of D0-meson nuclear modification factor can provide strong constraints into the mechanisms of in-medium energy loss and charm flow in the medium. The measurement of D0-meson elliptic flow in pPb collisions helps us understand the strength of charm quarks coupling to significantly reduced systems which demonstrate hydrodynamic properties. In this paper, the measurements of the D0-meson nuclear modification factor in PbPb collisions at 5.02 TeV together with the new measurement of D0-meson elliptic flow in high multiplicity pPb collisions at 5.02 TeV using the two-particle correlation method will be presented
Determination Of The Strong Coupling Constant Alpha(S)(M(Z)) From Measurements Of İnclusive W-+/- And Z Boson Production Cross Sections İn Proton-Proton Collisions At Root S=7 And 8 Tev
(The CMS Collaboration, 2020) Bilki, Burak; ., ve diğer.
Twelve measurements of inclusive cross sections of W-+/- and Z boson production, performed in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV, are compared with perturbative quantum chromodynamics calculations at next-to-next- to-leading order (NNLO) accuracy obtained with the CT14, HERAPDF2.0, MMHT14, and NNPDF3.0 parton distribution functions (PDFs). Data and theory agree well for all PDF sets, taking into account the experimental and theoretical uncertainties. A novel procedure is employed to extract the strong coupling constant at the Z pole mass from a detailed comparison of all the experimental fiducial cross sections to the corresponding NNLO theoretical predictions, yielding alpha S (m(Z)) = 0.1163(-0.0031)(+0.0024) (CT14), 0.1072(-0.0040)(+0.0043) (HERAPDF2.0), 0.1186 +/- 0. 0025 (MMHT14), and 0.1147 +/- 0.0023 (NNPDF3.0). Using the results obtained with the CT14 and MMHT14 PDFs, which yield the most robust and stable alpha(S)(mZ) extractions, a value alpha(S)(m(Z)) = 0.1175(-0.0028)(+0.0025) is determined.
Efficient Doxorubicin Loading to Isolated Dexosomes of Immature JAWSII Cells: Formulated and Characterized as the Bionanomaterial
(Scilit, 2020) Mutlu, Esra Cansever; Kaya, Özge; Wood, Matthew; Mager, Imre; Topkara, Kübra; ., ve diğer.
Immature dendritic cells (IDc), 'dexosomes', are promising natural nanomaterials for cancer diagnose and therapy. Dexosomes were isolated purely from small-scale-up production by using t25-cell-culture flasks. Total RNA was measured as 1.43 +/- 0.33 ng/10 cell. Despite the fact that they possessed a surface that is highly abundant in protein, this did not become a significant effect on the DOX loading amount. Ultrasonication was used for doxorubicin (DOX) loading into the IDc dexosomes. In accordance with the literature, three candidate DOX formulations were designed as IC50 values; dExoIII, 1.8 mu g/mL, dExoII, 1.2 mu g/mL, and dExoI, 0.6 mu g/mL, respectively. Formulations were evaluated by MTT test against highly metastatic A549 (CCL-185; ATTC) cell line. Confocal images of unloaded (naive) were obtained by CellMask(TM)membrane staining before DOX loading. Although, dexosome membranes were highly durable subsequent to ultrasonication, it was observed that dexosomes could not be stable above 70 degrees C during the SEM-image analyses. dExoIII displayed sustained release profile. It was found that dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) results were in good agreement with each other. Zeta potentials of loaded dexosomes have approximately between -15 to -20 mV; and, their sizes are 150 nm even after ultrasonication. IDcJAWSII dexosomes can be able to be utilized as the "BioNanoMaterial" after DOX loading via ultrasonication technique.
An Embedding Technique To Determine tt Backgrounds İn Proton-Proton Collision Data
(The CMS Collaboration, 2019) Bilki, Burak; Gürpınar Güler, Emine; ., ve diğer.
An embedding technique is presented to estimate standard model tt backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mm events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at p s = 13 TeV corresponding to an integrated luminosity of 41.5 fb-1.
Erratum: Search For A New Scalar Resonance Decaying To A Pair Of Z Bosons İn Proton-Proton Collisions At P S = 13 Tev
(The CMS Collaboration, 2019) Bilki, Burak; ., ve diğer.
A search for a new scalar resonance decaying to a pair of Z bosons is performed in the mass range from 130 GeV to 3 TeV, and for various width scenarios. The analysis is based on proton-proton collisions recorded by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb?1 at a center-of-mass energy of 13 TeV. The Z boson pair decays are reconstructed using the 4?, 2?2q, and 2?2? final states, where ? = e or ?. Both gluon fusion and electroweak production of the scalar resonance are considered, with a free parameter describing their relative cross sections. A dedicated categorization of events, based on the kinematic properties of associated jets, and matrix element techniques are employed for an optimal signal and background separation. A description of the interference between signal and background amplitudes for a resonance of an arbitrary width is included. No significant excess of events with respect to the standard model expectation is observed and limits are set on the product of the cross section for a new scalar boson and the branching fraction for its decay to ZZ for a large range of masses and widths. Open image in new window

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