Akincioglu, AkinAkbaba, YusufKose, Leyla PolatAkyuz, Leyla DemirkolGoksu, Sueleyman2024-03-132024-03-1320230040-40201464-5416https://doi.org/10.1016/j.tet.2023.133277https://hdl.handle.net/20.500.12662/4282We performed the racemic synthesis and asymmetric resolution of one 2-aminoindane and three 2-aminotertalins due to their crucial biological roles in the central nervous system (CNS). For this reason, desired (+/-)-2-aminoindane and (+/-)-2-aminotetralin derivatives were synthesized starting from appropriate reagents. While highly enantio pure (+)-39, (+)-40, and ( inverted exclamation )-40 were obtained from the reaction of racemic amines with (R)-O-acetylmandeloyl chloride followed by crystallization, hydrolysis with KOH and acidification with HCl, (S)-42 and (-)-43 were synthesized via the reaction of racemic amines with (S)-mandelic acid and hydrolysis.(c) 2023 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessDopaminergic compounds2-Aminotetralin2-AminoindaneAsymmetric resolutionMandelic acidO-acetylmandeloyl chlorideArticle10.1016/j.tet.2023.1332772-s2.0-85147304838Q3133WOS:000944002300001Q2