Eryildiz, Meltem2024-03-132024-03-1320231059-94951544-1024https://doi.org/10.1007/s11665-022-07490-0https://hdl.handle.net/20.500.12662/3557As a result of the combination of better mechanical and biological properties, gradient porous scaffolds are becoming more and more interesting alternatives for bioengineering and medical implants. In this study, drug-loaded functionally radial gradient scaffolds were investigated. Drug-loaded polylactic acid scaffolds with radial gradient porosities with different infill zones that mimic the heterogeneous bone structure were designed and manufactured. The PLA scaffolds with radial gradients were produced using the fused deposition modeling (FDM) method with gyroid infill Homogeneous porosity scaffolds were also tested to compare the results. The porosity, cell proliferation, drug release, and compressive strength of the fabricated 3D printed scaffolds were all tested in vitro. According to findings, the scaffolds with radial gradients contained the highest cell proliferation and drug release results but exhibited decreased mechanical strength because of the increased porosity. The drug-loaded radial gradient scaffolds fabricated in this work could be used as bone scaffolds to supply antibiotics, and they have compressive strength and cell proliferation levels that are comparable to real bones. [GRAPHICS] .eninfo:eu-repo/semantics/closedAccesscell proliferationcompressive strengthdrug releaseradial gradient porosityscaffoldArticle10.1007/s11665-022-07490-02-s2.0-8514012791642579Q2424932WOS:000870112700001Q3