Mutlu, Esra CanseverYildirim, Arzu BirinciYildirm, MuhammetFicai, AntonFicai, DenisaOktar, Faik NuzhetTitu, Mihail2024-03-132024-03-1320200170-08391436-2449https://doi.org/10.1007/s00289-019-02937-2https://hdl.handle.net/20.500.12662/3500This study aims the improvement of antibacterial and biocompatibility properties of electrospray ternary blends of chitosan/poly(ethylene glycol)/hyaluronic acid. It conserves microscale particle structure even after incorporating zinc oxide (ZnO), the zeolite Mobil Composition of Matter No. 41 (MCM41) and penicillin G during this technique. Three different electrospray (ESP) blend compositions (ESPI, ESPII and ESPIII) have been produced in order to improve both antibacterial activity against to bothgram-positive and gram-negativebacteria and biocompatibility. Results of FTIR spectroscopy and microscopy verified with SEM, EDS and AFM analyses. Hyaluronic acid surface has been specified definitely through ZnO-based ESPI surface composed of heterogeneously dispersed microparticles. Surface structures of ESPII and ESPIII have more homogenously dispersed microparticles as hill-valley surface by the aid of MCM 41-PEN. Antibacterial activity has been performed by Kirby-Bauer method. ESPI has good antibacterial activity against both gram-positive (S. aureusandS. epidermidis) and gram-negative bacteria (E. cloacea). Each electrospray film displayed good biocompatibility against to mouse fibroblast cell line L929 (ATTC number CCL-1). The highest amount of cell proliferation has been detected on ESPIII surface.eninfo:eu-repo/semantics/closedAccessElectrosprayHAZnOMCM 41MicroparticlesArticle10.1007/s00289-019-02937-22-s2.0-8507211715036757Q2365777WOS:000540604000018Q2