Demiryas, S.Caliskan, R.Saribas, S.Akkus, S.Gareayaghi, N.Kirmusaoglu, S.Kepil, N.2024-03-132024-03-1320201784-3227https://hdl.handle.net/20.500.12662/4127Introduction : As a component of the cag T4SS, the cagL gene is invoked in the translocation of CagA into host cells and is essential for the formation of cag PAI-associated pili between H. pylori and gastric epithelial cells. Aim : We aimed to investigate the clinical association of the cagL gene with other virulence Factors (VacA, CagA, EPIYA-C, and BabA protein) of GC, pylori strains isolated from GC, duodenal ulcer (DU), and non-ulcer dyspepsia (NUD) cases. Methods : The patient group (PC), including 47 patients (22 GC and 25 DU) and a 25 control group (CG= NUD) were included. Amplification of the H. pylori cagL, cagA, vacA, and babA2 genes and typing of EPIYA motifs were performed by PCR methods. Results : Sixty-one (84.7%) H. pylori strains were detected with cagL (93.6% in SG, 68% in CG). We detected a significant difference between SG and (1; for the presence of cagL (p=0.012) but no statistical comparison was done for (>= 2) EPIYA-C repeats In the comparison of H. pylori strains with cagA/vacAs1m1 and cagA/vacAs1m2 and babA2 for the presence of cagL we could not detect a significant difference (p=1). Conclusion : We detected a significant difference between groups for the presence of cagL genotype (p=0.012). The vacAs1m1 (OR: 2.829), genotypes increased the GC and DU risk by 2.8 times, while multiple (>= 2) EPIYA-C repeats incresed the GC and DU risk by 3.524 times. Gender (to be female) (OR: 0.454) decreased the GC and DU risk by inversly decreased in the multivariate analysis.eninfo:eu-repo/semantics/closedAccessHelicobacter pyloricytotoxin-associated gene A (cagA)cytotoxin-associated gene L(cagL)vacuolating cytotoxin A (vacA)Article2-s2.0-85094571724392333094584N/A38583WOS:000582321900004Q4