Caner, Vedat2026-01-312026-01-3120252296-2565https://doi.org./10.3389/fpubh.2025.1681513https://hdl.handle.net/20.500.12662/10809Introduction: Laboratory safety behavior is crucial for minimizing risks in high-hazard clinical settings, yet behavioral non-compliance persists as a leading cause of laboratory accidents despite established protocols. Methods: This study evaluated safety behavior among 92 personnel employed in genetic diagnostic laboratories in Istanbul using a validated 34-item safety behavior scale. Principal component analysis (PCA), multiple linear regression, and k-nearest neighbors (k-NN) classification were employed to analyze the data. Results: The analysis revealed three underlying behavioral dimensions: personal compliance, proactive behavior, and institutional engagement. Regression analysis indicated that perceived institutional support and the frequency of safety training were significant predictors of overall safety behavior (R-2 = 0.47, p < 0.001). Furthermore, the k-NN classifier utilizing PCA-derived components achieved an 88% accuracy rate in distinguishing high and low compliance profiles. Discussion: These findings underscore the utility of multivariate behavioral analytics in profiling laboratory safety behavior and highlight the potential of data-informed, classification-based strategies to enhance safety interventions. Adopting behaviorally tailored approaches to training and institutional support may markedly improve compliance and mitigate risk in laboratory environments.eninfo:eu-repo/semantics/openAccessoccupational safetylaboratory behaviorsafety behaviorbehavioral profilingclinical diagnosticsArticle10.3389/fpubh.2025.16815132-s2.0-10501852787141080846Q113WOS:001581314500001Q1