Akdeniz, Fatma TubaYaltırık, Cumhurİsbir, TurgaySümerkent, KadirYılmaz, Seda GüleçÖzdoğan, Selçuk2024-03-132024-03-1320202630-6050https://search.trdizin.gov.tr/yayin/detay/406849https://hdl.handle.net/20.500.12662/2476Objective: In this study, the main aim was to research whether decreased antioxidant activity was manifesting the intervertebral disc degeneration in a population in which the degeneration could be compatible with their ages.Material and Method: The study group consisted of 39 patients with lumbar disc degeneration (LDD) and 37 healthy controls. Patient data including age, symptoms, neurological examination findings, lumbar MRI findings, Oswestry Disability Index (ODI) scores, and Visual Analogue Scale of pain (VAS) were used. Human Glutathione peroxidase (GSH-Px) level was determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method.Results: Serum GSH-Px levels were significantly lower in the patients with LDD when compared to the healthy controls (p=0.011).Conclusions: In the present study, we demonstrated that, in addition to environmental factors, there is a correlation between GSHPx enzyme deficiency and lumbar disc degeneratioeninfo:eu-repo/semantics/openAccessArticle7126740684910