Ercan, Alev MeltemKaris, DenizhanAlkan, Fatma AteşUzan, Gülfıdan2024-03-132024-03-1320211305-49532587-1579https://doi.org/10.20515/otd.886366https://search.trdizin.gov.tr/yayin/detay/1119191https://hdl.handle.net/20.500.12662/2305Smoking induces inflammation and oxidative stress via radical production from chemicals resulting in cardiocerebrovascular and respiratory diseases, cancers, stroke and sudden death. Elements found in tobacco plant and tobacco smoke are absorbed into blood circulation and transferred into blood and peripheral tissues. The aim of the present study is to evaluate the alterations of serum nickel (Ni), silicium (Si), arsenic (As) and boron (B) levels in smokers. The study groups were categorized as individuals who quitted smoking (Group 1; n: 35; 15 female/20 male), who were smoking (Group 2; n:35; 13 female, 22 male) and who never-smoked (Group 3; n; 40; 20 female/20 male). Biochemical parameters were analyzed in Biochemistry Laboratory of Haseki Traning and Research Hospital. Serum element levels were measured using Inductively Coupled Plasma Atomic Emission Spectroscopy in Trace Element Laboratory of Biophysics Department of Cerrahpasa Medical Faculty at Istanbul University-Cerrahpasa. ANOVA test and Pearson’s correlation tests were used for statistical analysis and p < 0.05 was evaluated as statistically significant. Serum Ni levels of Group 2 were higher than the other study groups with no significance. Group 2 had statistically higher serum Si and As levels than Group 1 and Group 3 (p < 0.01, p < 0.05, respectively). There was no statistical significance by means of serum B levels among study groups. Increased serum levels of Si and As in smokers might induce atherosclerosis via inflammation, dyslipidemia and burden oxidative stress. Besides, higher serum Ni levels of smokers might reflect its toxic effects. However, serum B was lower in smokers probably related with its consumption in biological defence mechanisms. Monitorization of serum nickel, silicium, arsenic and boron levels should be considered as biomarkers for smokers.eninfo:eu-repo/semantics/openAccessArticle10.20515/otd.8863663814374111919143