Donmez, Aydin HaciMutlu, Yasar2026-01-312026-01-3120249.7984E+12https://doi.org./10.1145/3707172.3707184https://hdl.handle.net/20.500.12662/107379th International Conference on Biomedical Imaging Signal Processing -- OCT 18-20, 2024 -- Hong Kong, PEOPLES R CHINAThis study investigates the possible causes of radioactive leakage occurring during the Tc-99m generation process. For this purpose, hanging film examination and annular film thickness calculations are conducted within the needle of the generation unit using micro flow approximations. Additionally, local and line losses are calculated for each component in the Tc-99m generation setup, and the capillarity effect of the needle is also considered. Further modifications are made to the experimental setup to examine the effects of needle diameter, orifice influence, and an increase in the local loss coefficient. Finally, a two-phase, unsteady computational fluid dynamics study is conducted to gain detailed insights into fluid behavior during the elution process. As a result, it is recommended that a mechanical seal system positioned between the middle needle and the vacuum vial could provide an effective solution to the leakage problem.eninfo:eu-repo/semantics/closedAccessTc-99m generationTwo-phase flowLeakageMicroflowConference Object10.1145/3707172.37071842-s2.0-8521953109883N/A78WOS:001435181400012N/A