Kara, Sinem SipahiogluAtes, Mustafa YasinDeveci, GozdeCetinkaya, AhmetKahveci, Muhammet U.2024-03-132024-03-1320190887-624X1099-0518https://doi.org/10.1002/pola.29308https://hdl.handle.net/20.500.12662/3463Tetrazine mediated inverse Electron Demand Diels-Alder Reaction (IEDDA) is an important modification technique due to its high selectivity and super-fast kinetics. Incorporation of tetrazine moieties on polymer chains requires multistep synthetic pathways and a post-polymerization step leading to functional polymeric materials. Such approaches involve separate syntheses of polymer and the molecule which will be employed in modification. Herein, we introduce a straightforward synthetic approach for direct synthesis of tetrazine groups on polymers as side chains. As model systems, tetrazine functional poly(N-isopropylacrylamide)-and poly(ethylene glycol)-based polymers from corresponding precursor polymers with nitrile moieties as pendant groups are prepared and IEDDA Click Reaction is achieved with trans-cyclooctene derivatives. The click reaction is monitored by both NMR and UV-vis spectroscopies. (c) 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 673-680eninfo:eu-repo/semantics/closedAccessATRPDiels-Alder clickfunctionalization of polymersIEDDAmodificationpost-polymerizationtetrazineArticle10.1002/pola.293082-s2.0-850589411836806N/A67357WOS:000458269900002N/A