Biomimetic design and fabrication of thermally induced radial gradient shape memory scaffolds using fused deposition modeling (FDM) for bone tissue engineering
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Bone defects pose a significant challenge, often exceeding natural healing capabilities. This study explores the potential of thermally induced radial gradient shape memory (RGSM) scaffolds for minimally invasive bone repair. Inspired by the natural porosity gradient of bone, these scaffolds feature a high-porosity inner zone that mimics cancellous bone and a low-porosity outer zone that resembles cortical bone. When the relationship between porosity and key properties was investigated, it was found that lower-porosity RGSM scaffolds exhibited higher compressive strength but experienced higher residual strain and lower shape recovery ratio compared to their higher-porosity counterparts. Despite this trade-off, the gradient design successfully mimicked the natural bone structure, potentially enhancing osseointegration and bone regeneration. These results demonstrate the feasibility of RGSM scaffolds for bone tissue engineering. This holds promise for advancing minimally invasive surgical techniques and improving the treatment of bone defects.
Açıklama
Anahtar Kelimeler
Radial gradient scaffolds, fused deposition modeling, four-dimensional (4D) printing, shape memory behavior, polylactic acid (PLA), tissue engineering
Kaynak
Proceedings of The Institution of Mechanical Engineers Part L-Journal of Materials-Design and Applications
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
239
Sayı
1
