Isolated Optic Neuritis and Definite Multiple Sclerosis Conversion Features
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Identifying the factors associated with the development of multiple sclerosis (MS) in isolated optic neuritis (ION) is vital for early treatment decisions. Materials and Methods: In this study, we investigated definite MS conversion properties in patients with ION based on neurological, laboratory, magnetic resonance imaging (MRI), visual evoked potential (VEP), cerebrospinal fluid (CSF) examinations according to McDonald criteria 2005 and 2017. Results: Twenty-six of 41 patients (63.4%) with ION developed definite MS according to McDonald criteria 2005, and 32 patients (78%) developed it according to McDonald criteria 2017. We found that the risk of MS development after ION increased in the first 2 years (34.1%) according to McDonald Criteria 2005. VEP examinations revealed that prolonged latency in the P100 response supported the MS diagnosis. In the cranial MRI, the presence and excessiveness of white matter lesions were critical factors in predicting conversion from ON to MS. In addition, oligoclonal band (OCB) detection in the CSF helps predict MS conversion. Conclusion: Identifying the prognostic factors to understand MS development in ION and other clinically isolated syndromes (CIS) is essential when selecting patients for early treatment and considering early treatment options. The 2017 McDonald criteria provide a more rapid diagnosis of MS, but atypical clinical manifestations and misleading MRI findings must be carefully considered.
Açıklama
Anahtar Kelimeler
Multiple sclerosis, optic neuritis, oligoclonal band
Kaynak
Comprehensive medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
2
